biostudies-literature00460Unknown12(2)Awasthi NAsthma is a complex genetic disease. Vitamin D and vitamin D receptor (<i>VDR</i>) gene polymorphisms are involved in asthma pathogenesis. However, accurate inflammatory mechanisms and their role in <i>VDR</i> gene polymorphisms are unclear. The objective of this study was to investigate the association of <i>VDR</i> gene polymorphisms, <i>ApaI</i>, <i>FokI</i>, <i>TaqI</i>, and <i>BsmI</i> with asthma as compared to controls. Children (age 5-15 years) with a history of respiratory symptoms (wheeze, shortness of breath and chest tightness) were recruited as cases. Age matched children admitted with central nervous system disorders (encephalitis/seizures) without any respiratory complaints were recruited as controls after parental consent. Children with a clinical diagnosis of cystic fibrosis, congenital heart disease and whose parents did not consent for participation in the study were excluded. <i>VDR</i> gene polymorphisms were genotyped using PCR-RFLP method. One hundred and sixty asthmatics and one hundred controls were enrolled in this study. Mean age of the cases was 103.29±32.7 months and controls 94.24±30.52 months. Children with heterozygous (AC) genotype [OR=1.83, 95% CI=1.01-3.32, p=0.046] of ApaI polymorphism were found to be associated with the risk of asthma. Our findings suggest that <i>ApaI</i> polymorphism of <i>VDR</i> gene may contribute to asthma susceptibility among children.International journal of molecular epidemiology and genetics24-34https://www.ebi.ac.uk/biostudies/studies/S-EPMC8166730biostudies-literatureAssociation of vitamin D receptor gene polymorphisms in North Indian children with asthma: a case-control study.PMC8166730Awasthi NGupta SAwasthi SPandey S46falseAssociation of vitamin D receptor gene polymorphisms in North Indian children with asthma: a case-control study.Asthma is a complex genetic disease. Vitamin D and vitamin D receptor (<i>VDR</i>) gene polymorphisms are involved in asthma pathogenesis. However, accurate inflammatory mechanisms and their role in <i>VDR</i> gene polymorphisms are unclear. The objective of this study was to investigate the association of <i>VDR</i> gene polymorphisms, <i>ApaI</i>, <i>FokI</i>, <i>TaqI</i>, and <i>BsmI</i> with asthma as compared to controls. Children (age 5-15 years) with a history of respiratory symptoms (wheeze, shortness of breath and chest tightness) were recruited as cases. Age matched children admitted with central nervous system disorders (encephalitis/seizures) without any respiratory complaints were recruited as controls after parental consent. Children with a clinical diagnosis of cystic fibrosis, congenital heart disease and whose parents did not consent for participation in the study were excluded. <i>VDR</i> gene polymorphisms were genotyped using PCR-RFLP method. One hundred and sixty asthmatics and one hundred controls were enrolled in this study. Mean age of the cases was 103.29±32.7 months and controls 94.24±30.52 months. Children with heterozygous (AC) genotype [OR=1.83, 95% CI=1.01-3.32, p=0.046] of ApaI polymorphism were found to be associated with the risk of asthma. Our findings suggest that <i>ApaI</i> polymorphism of <i>VDR</i> gene may contribute to asthma susceptibility among children.2021-01-01T00:00:00Z20212022-02-10T14:11:05.615Z2022-02-10T14:11:05.615ZS-EPMC816673034093968