{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(5)"],"submitter":["Picard M"],"pubmed_abstract":["Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerp"],"journal":["Cell death and differentiation"],"pagination":["1532-1547"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8167112"],"repository":["biostudies-literature"],"pubmed_title":["Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients."],"pmcid":["PMC8167112"],"pubmed_authors":["Iebba V","Amon L","Scoazec JY","Becharef S","Gomperts Boneca I","Roberti MP","Routy B","Slowicka K","Malka D","Picard M","van Loo G","Ghiringhelli F","Vereecke L","Opolon P","Kroemer G","Richard C","Petta I","Lehmann CHK","Klein C","Zitvogel L","Rauber C","Tidjani Alou M","Berx G","Ly P","Pizzato E","Dudziak D","Yonekura S","Hollebecque A"],"additional_accession":[]},"is_claimable":false,"name":"Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.","description":"Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerp","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2026-04-08T07:18:00.072Z","creation":"2022-02-10T14:05:19.941Z"},"accession":"S-EPMC8167112","cross_references":{"pubmed":["33262469"],"doi":["10.1038/s41418-020-00684-w"]}}