biostudies-literatureMacInnis RJCancer AustraliaNCATS NIH HHSAustralian National HealthVictorian Health Promotion FoundationVictorian Breast Cancer Research ConsortiumQueensland Cancer FundCancer Councils of New South WalesNational Breast Cancer FoundationNew South Wales Cancer CouncilAustralian National Breast Cancer FoundationBreast Cancer Research FoundationKathleen Cuningham Foundation Consortium for Research into Familial Breast CancerUS National Cancer InstituteMedical Research CouncilUS National Institute of HealthThe Australian Breast Cancer Family RegistryNational Health and Medical Research CouncilNCI NIH HHSCancer Foundation of Western AustraliaBreast Cancer Family Registry785-791https://www.ebi.ac.uk/biostudies/studies/S-EPMC8168075biostudies-literatureUnknown113(6)<h4>Background</h4>Clinical guidelines often use predicted lifetime risk from birth to define criteria for making decisions regarding breast cancer screening rather than thresholds based on absolute 5-year risk from current age.<h4>Methods</h4>We used the Prospective Family Cohort Study of 14 657 women without breast cancer at baseline in which, during a median follow-up of 10 years, 482 women were diagnosed with invasive breast cancer. We examined the performances of the International Breast Cancer Intervention Study (IBIS) and Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk models when using the alternative thresholds by comparing predictions based on 5-year risk with those based on lifetime risk from birth and remaining lifetime risk. AlJournal of the National Cancer InstituteComparing 5-Year and Lifetime Risks of Breast Cancer using the Prospective Family Study Cohort.PMC8168075809195288704PRAC-17-004UL1 TR001863UL1 TR0025381100868145684IF 17 kConFab454508UM1 CA164920R01 CA159868RO1CA159868U01 CA164920U01CA164920Goldgar DLiao YMilne RLSouthey MCKnight JAAndrulis ILBuchsbaum RChung WKPhillips KADite GSBuys SSHopper JLTerry MBWhittemore ASGiles GGkConFab InvestigatorsKurian AWDaly MBMacInnis RJJohn EMZeinomar NfalseComparing 5-Year and Lifetime Risks of Breast Cancer using the Prospective Family Study Cohort.<h4>Background</h4>Clinical guidelines often use predicted lifetime risk from birth to define criteria for making decisions regarding breast cancer screening rather than thresholds based on absolute 5-year risk from current age.<h4>Methods</h4>We used the Prospective Family Cohort Study of 14 657 women without breast cancer at baseline in which, during a median follow-up of 10 years, 482 women were diagnosed with invasive breast cancer. We examined the performances of the International Breast Cancer Intervention Study (IBIS) and Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk models when using the alternative thresholds by comparing predictions based on 5-year risk with those based on lifetime risk from birth and remaining lifetime risk. Al2021-01-01T00:00:00Z2021 Jun2026-07-16T10:39:16.166Z2026-07-09T10:51:36.898ZS-EPMC81680753330102210.1093/jnci/djaa178