biostudies-literatureKoole JLNICHD NIH HHSEuropean Research Area NetworkWereld Kanker Onderzoek FondsHealth FoundationNational Cancer InstituteNHGRI NIH HHSNCI NIH HHS1468-1481https://www.ebi.ac.uk/biostudies/studies/S-EPMC8168355biostudies-literatureUnknown113(6)<h4>Background</h4>B vitamins have been associated with the risk and progression of colorectal cancer (CRC), given their central roles in nucleotide synthesis and methylation, yet their association with quality of life in established CRC is unclear.<h4>Objectives</h4>To investigate whether quality of life 6 months postdiagnosis is associated with: 1) circulating concentrations of B vitamins and related biomarkers 6 months postdiagnosis; 2) changes in these concentrations between diagnosis and 6 months postdiagnosis; 3) B-vitamin supplement use 6 months postdiagnosis; and 4) changes in B-vitamin supplement use between diagnosis and 6 months postdiagnosis.<h4>Methods</h4>We included 1676 newly diagnosed stage I-III CRC patients from 3 prospective European cohorts. Circulating concentrations The American journal of clinical nutritionCirculating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.PMC8168355R01 CA1891842014/1179K12 HD04348300005739R01 CA207371CA1891842014-68772013-6397U01 CA206110T32 HG008962Gigic BUlrich ABOse JLin TWesselink EVickers KUlvik AGumpenberger TUeland PMKok DEvan Halteren HKJanssen-Heijnen MLGWeijenberg MPLi CISchrotz-King PHabermann NUlrich CMBreukink SOMidttun OKruyt FMKeulen ETPBrezina SHolowatyj ANChang-Claude JKoole JLSchneider MABaierl ABohm Jvan Duijvendijk Pvan Duijnhoven FJBPeoples ARBours MJLKampman EGeijsen AJMRBrenner HKiblawi RGsur Ade Wilt JHWvan Roekel EHHoffmeister MfalseCirculating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.<h4>Background</h4>B vitamins have been associated with the risk and progression of colorectal cancer (CRC), given their central roles in nucleotide synthesis and methylation, yet their association with quality of life in established CRC is unclear.<h4>Objectives</h4>To investigate whether quality of life 6 months postdiagnosis is associated with: 1) circulating concentrations of B vitamins and related biomarkers 6 months postdiagnosis; 2) changes in these concentrations between diagnosis and 6 months postdiagnosis; 3) B-vitamin supplement use 6 months postdiagnosis; and 4) changes in B-vitamin supplement use between diagnosis and 6 months postdiagnosis.<h4>Methods</h4>We included 1676 newly diagnosed stage I-III CRC patients from 3 prospective European cohorts. Circulating concentrations 2021-01-01T00:00:00Z2021 Jun2026-04-08T17:54:41.369Z2025-02-18T23:32:30.553ZS-EPMC81683553366806910.1093/ajcn/nqaa422