{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Zhang C"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["The mutation pattern of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has changed constantly during worldwide community transmission of this virus. However, the reasons for the changes in mutation patterns are still unclear. Accordingly, in this study, we present a comprehensive analysis of over 300 million peptides derived from 13,432 SARS-CoV-2 strains harboring 4,420 amino acid mutations to analyze the potential selective pressure of the host immune system and reveal the driver of mutations in circulating SARS-CoV-2 isolates. The results showed that the nonstructural protein ORF1ab and the structural protein Spike were most susceptible to mutations. Furthermore, mutations in cross-reactive T-cell epitopes between SARS-CoV-2 and seasonal human coronavirus may help SARS-CoV"],"journal":["Frontiers in microbiology"],"pagination":["599562"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8169977"],"repository":["biostudies-literature"],"pubmed_title":["Antigenic Evolution on a Global Scale Reveals the Potential Natural Selection of Severe Acute Respiratory Syndrome-Coronavirus 2 by Pre-existing Cross-Reactive T-Cell Immunity."],"pmcid":["PMC8169977"],"pubmed_authors":["Leng Q","Jin X","Qiu T","Chen X","Zhang C","Qiu L"],"additional_accession":[]},"is_claimable":false,"name":"Antigenic Evolution on a Global Scale Reveals the Potential Natural Selection of Severe Acute Respiratory Syndrome-Coronavirus 2 by Pre-existing Cross-Reactive T-Cell Immunity.","description":"The mutation pattern of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has changed constantly during worldwide community transmission of this virus. However, the reasons for the changes in mutation patterns are still unclear. Accordingly, in this study, we present a comprehensive analysis of over 300 million peptides derived from 13,432 SARS-CoV-2 strains harboring 4,420 amino acid mutations to analyze the potential selective pressure of the host immune system and reveal the driver of mutations in circulating SARS-CoV-2 isolates. The results showed that the nonstructural protein ORF1ab and the structural protein Spike were most susceptible to mutations. Furthermore, mutations in cross-reactive T-cell epitopes between SARS-CoV-2 and seasonal human coronavirus may help SARS-CoV","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-08T01:22:43.639Z","creation":"2022-02-10T14:11:26.569Z"},"accession":"S-EPMC8169977","cross_references":{"pubmed":["34093454"],"doi":["10.3389/fmicb.2021.599562"]}}