{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Fan S"],"funding":["Natural Science Foundation of Shanghai","National Natural Science Foundation of China"],"pubmed_abstract":["The fungal pathogen <i>Candida auris</i> has emerged as a new threat to human health. We previously reported the first isolate of <i>C. auris</i> (BJCA001) in China, which belongs to the South Asian clade (I) and was susceptible to all antifungals tested. In this study, we report the isolation of a drug-resistant <i>C. auris</i> strain (BJCA002) from the same city (Beijing). Strain BJCA002 belongs to the South African clade (III) and is resistant to fluconazole and amphotericin B based on the tentative MIC breakpoints. Taking advantage of the two isolates with distinct antifungal susceptibility and genetic origins, we performed a biological and genomic comparative study. Besides antifungal susceptibility, strains BJCA001 and BJCA002 showed differences in multiple aspects including morpholo"],"journal":["Virulence"],"pagination":["1388-1399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8172162"],"repository":["biostudies-literature"],"pubmed_title":["A biological and genomic comparison of a drug-resistant and a drug-susceptible strain of <i>Candida auris</i> isolated from Beijing, China."],"pmcid":["PMC8172162"],"pubmed_authors":["Zhan P","Bing J","Hu T","Huang Y","Huang G","Du H","Jiang N","Fan S","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"A biological and genomic comparison of a drug-resistant and a drug-susceptible strain of <i>Candida auris</i> isolated from Beijing, China.","description":"The fungal pathogen <i>Candida auris</i> has emerged as a new threat to human health. We previously reported the first isolate of <i>C. auris</i> (BJCA001) in China, which belongs to the South Asian clade (I) and was susceptible to all antifungals tested. In this study, we report the isolation of a drug-resistant <i>C. auris</i> strain (BJCA002) from the same city (Beijing). Strain BJCA002 belongs to the South African clade (III) and is resistant to fluconazole and amphotericin B based on the tentative MIC breakpoints. Taking advantage of the two isolates with distinct antifungal susceptibility and genetic origins, we performed a biological and genomic comparative study. Besides antifungal susceptibility, strains BJCA001 and BJCA002 showed differences in multiple aspects including morpholo","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-06-19T03:09:31.888Z","creation":"2022-02-10T14:27:51.823Z"},"accession":"S-EPMC8172162","cross_references":{"pubmed":["34060424"],"doi":["10.1080/21505594.2021.1928410"]}}