biostudies-literatureUnknown12(1)Fan SNatural Science Foundation of ShanghaiNational Natural Science Foundation of ChinaThe fungal pathogen <i>Candida auris</i> has emerged as a new threat to human health. We previously reported the first isolate of <i>C. auris</i> (BJCA001) in China, which belongs to the South Asian clade (I) and was susceptible to all antifungals tested. In this study, we report the isolation of a drug-resistant <i>C. auris</i> strain (BJCA002) from the same city (Beijing). Strain BJCA002 belongs to the South African clade (III) and is resistant to fluconazole and amphotericin B based on the tentative MIC breakpoints. Taking advantage of the two isolates with distinct antifungal susceptibility and genetic origins, we performed a biological and genomic comparative study. Besides antifungal susceptibility, strains BJCA001 and BJCA002 showed differences in multiple aspects including morpholoVirulence1388-1399https://www.ebi.ac.uk/biostudies/studies/S-EPMC8172162biostudies-literatureA biological and genomic comparison of a drug-resistant and a drug-susceptible strain of <i>Candida auris</i> isolated from Beijing, China.PMC8172162Zhan PBing JHu THuang YHuang GDu HJiang NFan SChen DfalseA biological and genomic comparison of a drug-resistant and a drug-susceptible strain of <i>Candida auris</i> isolated from Beijing, China.The fungal pathogen <i>Candida auris</i> has emerged as a new threat to human health. We previously reported the first isolate of <i>C. auris</i> (BJCA001) in China, which belongs to the South Asian clade (I) and was susceptible to all antifungals tested. In this study, we report the isolation of a drug-resistant <i>C. auris</i> strain (BJCA002) from the same city (Beijing). Strain BJCA002 belongs to the South African clade (III) and is resistant to fluconazole and amphotericin B based on the tentative MIC breakpoints. Taking advantage of the two isolates with distinct antifungal susceptibility and genetic origins, we performed a biological and genomic comparative study. Besides antifungal susceptibility, strains BJCA001 and BJCA002 showed differences in multiple aspects including morpholo2021-01-01T00:00:00Z2021 Dec2026-06-19T03:09:31.888Z2022-02-10T14:27:51.823ZS-EPMC81721623406042410.1080/21505594.2021.1928410