{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hojo M"],"funding":["Ministry of Health, Labour and Welfare"],"pagination":["2185-2198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8177772"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(6)"],"pubmed_abstract":["A rat model of mesothelioma development by peritoneal injection of multiwalled carbon nanotube (MWCNT) has been established and found to be useful to understand the mechanisms underlying fibrous particles-associated carcinogenesis. Its detailed histological sequence, however, remains largely obscure. We therefore aimed to assess the time-course of mesothelioma development by MWCNT and evaluate a set of lipoprotein-related molecules as potential mechanism-based biomarkers for the phenomenon. Male Fischer 344 rats were injected intraperitoneally (ip) with MWCNT (MWNT-7) at 1 mg/kg body weight, and necropsied at 8, 16, 24, 32, or 42 wk after injection. For biochemical analyses of the lipoprotein-related molecules, more samples, including severe mesothelioma cases, were obtained from 2 other c"],"journal":["Cancer science"],"pubmed_title":["Histological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins."],"pmcid":["PMC8177772"],"funding_grant_id":["H27‐Kagaku‐Shitei‐004","H30‐Kagaku‐Shitei‐004","H30-Kagaku-Shitei-004","H27-Kagaku-Shitei-004"],"pubmed_authors":["Sakamoto Y","Hojo M","Ohnuki A","Yamamoto Y","Kanno J","Suzuki J","Inomata A","Moriyasu T","Maeno A","Hirose A","Taquahashi Y","Nakae D"],"additional_accession":[]},"is_claimable":false,"name":"Histological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins.","description":"A rat model of mesothelioma development by peritoneal injection of multiwalled carbon nanotube (MWCNT) has been established and found to be useful to understand the mechanisms underlying fibrous particles-associated carcinogenesis. Its detailed histological sequence, however, remains largely obscure. We therefore aimed to assess the time-course of mesothelioma development by MWCNT and evaluate a set of lipoprotein-related molecules as potential mechanism-based biomarkers for the phenomenon. Male Fischer 344 rats were injected intraperitoneally (ip) with MWCNT (MWNT-7) at 1 mg/kg body weight, and necropsied at 8, 16, 24, 32, or 42 wk after injection. For biochemical analyses of the lipoprotein-related molecules, more samples, including severe mesothelioma cases, were obtained from 2 other c","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-25T21:28:17.114Z","creation":"2022-02-10T14:41:44.377Z"},"accession":"S-EPMC8177772","cross_references":{"pubmed":["33665882"],"doi":["10.1111/cas.14873"]}}