biostudies-literatureHojo MMinistry of Health, Labour and Welfare2185-2198https://www.ebi.ac.uk/biostudies/studies/S-EPMC8177772biostudies-literatureUnknown112(6)A rat model of mesothelioma development by peritoneal injection of multiwalled carbon nanotube (MWCNT) has been established and found to be useful to understand the mechanisms underlying fibrous particles-associated carcinogenesis. Its detailed histological sequence, however, remains largely obscure. We therefore aimed to assess the time-course of mesothelioma development by MWCNT and evaluate a set of lipoprotein-related molecules as potential mechanism-based biomarkers for the phenomenon. Male Fischer 344 rats were injected intraperitoneally (ip) with MWCNT (MWNT-7) at 1 mg/kg body weight, and necropsied at 8, 16, 24, 32, or 42 wk after injection. For biochemical analyses of the lipoprotein-related molecules, more samples, including severe mesothelioma cases, were obtained from 2 other cCancer scienceHistological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins.PMC8177772H27‐Kagaku‐Shitei‐004H30‐Kagaku‐Shitei‐004H30-Kagaku-Shitei-004H27-Kagaku-Shitei-004Sakamoto YHojo MOhnuki AYamamoto YKanno JSuzuki JInomata AMoriyasu TMaeno AHirose ATaquahashi YNakae DfalseHistological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins.A rat model of mesothelioma development by peritoneal injection of multiwalled carbon nanotube (MWCNT) has been established and found to be useful to understand the mechanisms underlying fibrous particles-associated carcinogenesis. Its detailed histological sequence, however, remains largely obscure. We therefore aimed to assess the time-course of mesothelioma development by MWCNT and evaluate a set of lipoprotein-related molecules as potential mechanism-based biomarkers for the phenomenon. Male Fischer 344 rats were injected intraperitoneally (ip) with MWCNT (MWNT-7) at 1 mg/kg body weight, and necropsied at 8, 16, 24, 32, or 42 wk after injection. For biochemical analyses of the lipoprotein-related molecules, more samples, including severe mesothelioma cases, were obtained from 2 other c2021-01-01T00:00:00Z2021 Jun2025-04-25T21:28:17.114Z2022-02-10T14:41:44.377ZS-EPMC81777723366588210.1111/cas.14873