biostudies-literatureZhong SNational Natural Science Foundation of ChinaYoung Talents Program of Jiangsu Cancer HospitalHuai‘an Natural Science Research Plane11561https://www.ebi.ac.uk/biostudies/studies/S-EPMC8183431biostudies-literatureUnknown9N6-methyladenosine (m⁶A) modification has been shown to participate in tumorigenesis and metastasis of human cancers. The present study aimed to investigate the roles of m⁶A RNA methylation regulators in breast cancer. We used LASSO regression to identify m⁶A-related gene signature predicting breast cancer survival with the datasets downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (TCGA). RNA-Seq data of 3409 breast cancer patients from GSE96058 and 1097 from TCGA were used in present study. A 10 m⁶A-related gene signature associated with prognosis was identified from 22 m⁶A RNA methylation regulators. The signature divided patients into low- and high-risk group. High-risk patients had a worse prognosis than the low-PeerJThe m⁶A-related gene signature for predicting the prognosis of breast cancer.PMC818343181602551HAB201816QL201810Feng JZhong SZhou SLin ZChen HMao LfalseThe m⁶A-related gene signature for predicting the prognosis of breast cancer.N6-methyladenosine (m⁶A) modification has been shown to participate in tumorigenesis and metastasis of human cancers. The present study aimed to investigate the roles of m⁶A RNA methylation regulators in breast cancer. We used LASSO regression to identify m⁶A-related gene signature predicting breast cancer survival with the datasets downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (TCGA). RNA-Seq data of 3409 breast cancer patients from GSE96058 and 1097 from TCGA were used in present study. A 10 m⁶A-related gene signature associated with prognosis was identified from 22 m⁶A RNA methylation regulators. The signature divided patients into low- and high-risk group. High-risk patients had a worse prognosis than the low-2021-01-01T00:00:00Z20212026-05-08T00:19:46.559Z2022-02-10T15:42:36.329ZS-EPMC81834313414149210.7717/peerj.11561