biostudies-literatureLacy GDNCATS NIH HHSNEI NIH HHSNational Institutes of Health137-146https://www.ebi.ac.uk/biostudies/studies/S-EPMC8184579biostudies-literatureUnknown225<h4>Objective</h4>We sought to construct and validate a patient-reported outcome measure for screening and monitoring vision-related anxiety in patients with inherited retinal degenerations.<h4>Design</h4>Item-response theory and graded response modeling to quantitatively validate questionnaire items generated from qualitative interviews and patient feedback.<h4>Methods</h4>Patients at the Kellogg Eye Center (University of Michigan, Ann Arbor, Michigan, USA) with a clinical diagnosis of an inherited retinal degeneration (n = 128) participated in an interviewer-administered questionnaire. The questionnaire consisted of 166 items, 26 of which pertained to concepts of "worry" and "anxiety." The subset of vision-related anxiety questions was analyzed by a graded response model using the Cai MeAmerican journal of ophthalmologyThe Michigan Vision-Related Anxiety Questionnaire: A Psychosocial Outcomes Measure for Inherited Retinal Degenerations.PMC8184579TL1 TR002242K23 EY027848K23 EY026985K12 EY022299Santos EPFahim ATBaig NYu GPopova LTRakine HYAbuzaitoun RStelmack JAJayasundera KTBranham KHSwenor BKLichter PRLacy GDEhrlich JRAbalem MFAndrews CAMusch DCDagnelie GfalseThe Michigan Vision-Related Anxiety Questionnaire: A Psychosocial Outcomes Measure for Inherited Retinal Degenerations.<h4>Objective</h4>We sought to construct and validate a patient-reported outcome measure for screening and monitoring vision-related anxiety in patients with inherited retinal degenerations.<h4>Design</h4>Item-response theory and graded response modeling to quantitatively validate questionnaire items generated from qualitative interviews and patient feedback.<h4>Methods</h4>Patients at the Kellogg Eye Center (University of Michigan, Ann Arbor, Michigan, USA) with a clinical diagnosis of an inherited retinal degeneration (n = 128) participated in an interviewer-administered questionnaire. The questionnaire consisted of 166 items, 26 of which pertained to concepts of "worry" and "anxiety." The subset of vision-related anxiety questions was analyzed by a graded response model using the Cai Me2021-01-01T00:00:00Z2021 May2025-04-05T10:03:48.795Z2025-04-05T10:03:48.795ZS-EPMC81845793330969210.1016/j.ajo.2020.12.001