{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nadanaka S"],"funding":["Ministry of Education, Culture, Sports, Science and Technology"],"pagination":["659428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8185021"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Basal-like breast cancer is characterized by an aggressive clinical outcome and presence of metastasis, for which effective therapies are unavailable. We have previously shown that chondroitin 4-<i>O</i>-sulfotransferase-1 (C4ST-1) controls the invasive properties of the basal-like breast cancer cell line BT-549 by inducing matrix metalloproteinase (MMP) expression through the N-cadherin/β-catenin pathway. Here we report that C4ST-1 controls the proliferation of BT-549 cells via the MMP-dependent cleavage of syndecan-1. Syndecan-1 is a membrane-bound proteoglycan associated with an aggressive phenotype and poor prognosis in breast cancer. In addition, the cleavage of syndecan-1 at a specific juxtamembrane cleavage site is implicated in the pathophysiological response in breast cancer. Knoc"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation."],"pmcid":["PMC8185021"],"funding_grant_id":["25293014","23110003","20H03386","25460080"],"pubmed_authors":["Nadanaka S","Kitagawa H","Bai Y"],"additional_accession":[]},"is_claimable":false,"name":"Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation.","description":"Basal-like breast cancer is characterized by an aggressive clinical outcome and presence of metastasis, for which effective therapies are unavailable. We have previously shown that chondroitin 4-<i>O</i>-sulfotransferase-1 (C4ST-1) controls the invasive properties of the basal-like breast cancer cell line BT-549 by inducing matrix metalloproteinase (MMP) expression through the N-cadherin/β-catenin pathway. Here we report that C4ST-1 controls the proliferation of BT-549 cells via the MMP-dependent cleavage of syndecan-1. Syndecan-1 is a membrane-bound proteoglycan associated with an aggressive phenotype and poor prognosis in breast cancer. In addition, the cleavage of syndecan-1 at a specific juxtamembrane cleavage site is implicated in the pathophysiological response in breast cancer. Knoc","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-10T05:33:34.991Z","creation":"2022-02-10T14:32:48.397Z"},"accession":"S-EPMC8185021","cross_references":{"pubmed":["34113616"],"doi":["10.3389/fcell.2021.659428"]}}