{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Lu J"],"pubmed_abstract":["Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated with post-discharge survival, and there is a paucity of prognostic markers associated with TA-AAD. Here, we identify nine candidate proteins specific for patietns with TA-AAD in a cross-sectional dataset by unbiased protein screening and in-depth bioinformatic analyses. In addition, we explore their association with short-term and long-term mortality in a derivation cohort of patients with TA-AAD, including an internal (n = 300) and external (n = 236) dataset. An elevated osteoprotegerin (OPG)/tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) ratio was the strongest predictor of overall, 30-day, post-30-day mortality in both datasets and was confirmed to be a strong predictor of mortality in an independent validation cohort (n = 400). Based on OPG/TRAIL ratio-guided risk stratification, patients at high risk (>33) had a higher 1-year mortality (55.6% vs. 4.3%; 68.2% vs. 2.6%) than patients at low risk (<4) in both cohorts. In Conclusion, we show that an elevated OPG/TRAIL ratio is associated with a significant increase in short-term and long-term mortality in patients with TA-AAD."],"journal":["Nature communications"],"pagination":["3401"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8185077"],"repository":["biostudies-literature"],"pubmed_title":["OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection."],"pmcid":["PMC8185077"],"pubmed_authors":["Pan X","Wu L","Zhang H","Li P","Yuan H","Li Y","Zhu J","Huang Y","Ou J","Lu J","Ma K","Du J","Duan W"],"additional_accession":[]},"is_claimable":false,"name":"OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection.","description":"Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated with post-discharge survival, and there is a paucity of prognostic markers associated with TA-AAD. Here, we identify nine candidate proteins specific for patietns with TA-AAD in a cross-sectional dataset by unbiased protein screening and in-depth bioinformatic analyses. In addition, we explore their association with short-term and long-term mortality in a derivation cohort of patients with TA-AAD, including an internal (n = 300) and external (n = 236) dataset. An elevated osteoprotegerin (OPG)/tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) ratio was the strongest predictor of overall, 30-day, post-30-day mortality in both datasets and was confirmed to be a strong predictor of mortality in an independent validation cohort (n = 400). Based on OPG/TRAIL ratio-guided risk stratification, patients at high risk (>33) had a higher 1-year mortality (55.6% vs. 4.3%; 68.2% vs. 2.6%) than patients at low risk (<4) in both cohorts. In Conclusion, we show that an elevated OPG/TRAIL ratio is associated with a significant increase in short-term and long-term mortality in patients with TA-AAD.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2022-02-10T14:32:55.586Z","creation":"2022-02-10T14:32:55.586Z"},"accession":"S-EPMC8185077","cross_references":{"pubmed":["34099729"],"doi":["10.1038/s41467-021-23787-5"]}}