{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rooney JP"],"funding":["NIEHS NIH HHS","NIEHS"],"pagination":["104920"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8186434"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122"],"pubmed_abstract":["The in vivo rabbit test is the benchmark against which new approach methodologies for skin irritation are usually compared. No alternative method offers a complete replacement of animal use for this endpoint for all regulatory applications. Variability in the animal reference data may be a limiting factor in identifying a replacement. We established a curated data set of 2624 test records, representing 990 substances, each tested at least twice, to characterize the reproducibility of the in vivo assay. Methodological deviations from guidelines were noted, and multiple data sets with differing tolerances for deviations were created. Conditional probabilities were used to evaluate the reproducibility of the in vivo method in identification of U.S. Environmental Protection Agency or Globally "],"journal":["Regulatory toxicology and pharmacology : RTP"],"pubmed_title":["Analysis of variability in the rabbit skin irritation assay."],"pmcid":["PMC8186434"],"funding_grant_id":["HHSN273201500010C"],"pubmed_authors":["Ceger P","Choksi NY","Daniel AB","Truax J","Kleinstreuer N","Rooney JP","Allen D"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of variability in the rabbit skin irritation assay.","description":"The in vivo rabbit test is the benchmark against which new approach methodologies for skin irritation are usually compared. No alternative method offers a complete replacement of animal use for this endpoint for all regulatory applications. Variability in the animal reference data may be a limiting factor in identifying a replacement. We established a curated data set of 2624 test records, representing 990 substances, each tested at least twice, to characterize the reproducibility of the in vivo assay. Methodological deviations from guidelines were noted, and multiple data sets with differing tolerances for deviations were created. Conditional probabilities were used to evaluate the reproducibility of the in vivo method in identification of U.S. Environmental Protection Agency or Globally ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-19T18:19:00.206Z","creation":"2025-04-19T18:19:00.206Z"},"accession":"S-EPMC8186434","cross_references":{"pubmed":["33757807"],"doi":["10.1016/j.yrtph.2021.104920"]}}