{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["O'Connor SA"],"funding":["National Institute of Neurological Disorders and Stroke","Pew Charitable Trusts","National Cancer Institute","NCI NIH HHS","NINDS NIH HHS","Armed Forces Research Institute of Medical Sciences"],"pagination":["e9522"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8186478"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(6)"],"pubmed_abstract":["Single-cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we used scRNA-seq to examine the cell cycle states of expanding human neural stem cells (hNSCs). From these data, we constructed a cell cycle classifier that identifies traditional cell cycle phases and a putative quiescent-like state in neuroepithelial-derived cell types during mammalian neurogenesis and in gliomas. The Neural G0 markers are enriched with quiescent NSC genes and other neurodevelopmental markers found in non-dividing neural progenitors. Putative glioblastoma stem-like cells were significantly enriched in the Neural G0 cell population. Neural G0 cell populations and gene expression are significantly associated with less a"],"journal":["Molecular systems biology"],"pubmed_title":["Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma."],"pmcid":["PMC8186478"],"funding_grant_id":["T32CA080416","T32 CA009657","R21 CA232244","P30 CA015704","P30CA15704","T32 CA080416","R21CA170722","5R21CA232244","R21 CA170722","CA100735","R01 NS119650","R01NS119650","R01 CA190957","R01CA190957"],"pubmed_authors":["Patel A","Corrin P","Hoellerbauer P","O'Connor SA","Basom R","Feldman HM","Arora S","Toledo CM","Kufeld M","Delrow J","Trapnell C","Paddison PJ","Plaisier CL","McFaline-Figueroa JL","Carter L","Bolouri H","Pollard SM"],"additional_accession":[]},"is_claimable":false,"name":"Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma.","description":"Single-cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we used scRNA-seq to examine the cell cycle states of expanding human neural stem cells (hNSCs). From these data, we constructed a cell cycle classifier that identifies traditional cell cycle phases and a putative quiescent-like state in neuroepithelial-derived cell types during mammalian neurogenesis and in gliomas. The Neural G0 markers are enriched with quiescent NSC genes and other neurodevelopmental markers found in non-dividing neural progenitors. Putative glioblastoma stem-like cells were significantly enriched in the Neural G0 cell population. Neural G0 cell populations and gene expression are significantly associated with less a","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-09T06:46:43.739Z","creation":"2022-02-10T15:02:52.044Z"},"accession":"S-EPMC8186478","cross_references":{"pubmed":["34101353"],"doi":["10.15252/msb.20209522"]}}