{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duclot F"],"funding":["NIA NIH HHS","NIMH NIH HHS","National Institute of Mental Health","National Institute on Aging"],"pagination":["141-151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8187463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(1)"],"pubmed_abstract":["<h4>Background</h4>The ability to form enduring social bonds is characteristic of human nature, and impairments in social affiliation are central features of severe neuropsychiatric disorders including autism spectrum disorder and schizophrenia. Owing to its ability to form long-term pair-bonds, the socially monogamous prairie vole has emerged as an excellent model to study the neurobiology of social attachment. Despite the enduring nature of the bond, however, surprisingly few genes have been implicated in the pair-bonding process in either sex.<h4>Methods</h4>Male and female prairie voles (Microtus ochrogaster) were cohabitated with an opposite-sex partner for 24 hours or 3 weeks, and transcriptomic regulations in the nucleus accumbens were measured by RNA sequencing.<h4>Results</h4>We f"],"journal":["Biological psychiatry"],"pubmed_title":["Transcriptomic Regulations Underlying Pair-bond Formation and Maintenance in the Socially Monogamous Male and Female Prairie Vole."],"pmcid":["PMC8187463"],"funding_grant_id":["R01 MH109450","R01 AG064420","R01 MH108527","R01 MH125408","R01 MH058616"],"pubmed_authors":["Koutakis P","Sailer L","Duclot F","Wang Z","Kabbaj M"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic Regulations Underlying Pair-bond Formation and Maintenance in the Socially Monogamous Male and Female Prairie Vole.","description":"<h4>Background</h4>The ability to form enduring social bonds is characteristic of human nature, and impairments in social affiliation are central features of severe neuropsychiatric disorders including autism spectrum disorder and schizophrenia. Owing to its ability to form long-term pair-bonds, the socially monogamous prairie vole has emerged as an excellent model to study the neurobiology of social attachment. Despite the enduring nature of the bond, however, surprisingly few genes have been implicated in the pair-bonding process in either sex.<h4>Methods</h4>Male and female prairie voles (Microtus ochrogaster) were cohabitated with an opposite-sex partner for 24 hours or 3 weeks, and transcriptomic regulations in the nucleus accumbens were measured by RNA sequencing.<h4>Results</h4>We f","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-03T23:17:24.255Z","creation":"2025-04-03T23:17:24.255Z"},"accession":"S-EPMC8187463","cross_references":{"pubmed":["33549315"],"doi":["10.1016/j.biopsych.2020.11.022"]}}