{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu S"],"funding":["Key Project of Shanghai Science and Technology Commission","National Key R&amp;D Program of China","Shanghai Key Laboratory of Magnetic Resonance","National Natural Science Foundation of China","National Funds for Distinguished Young Scientists","China Postdoctoral Science Foundation"],"pagination":["e2002548"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8188217"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(11)"],"pubmed_abstract":["Timely detection of liver fibrosis by X-ray computed tomography (CT) can prevent its progression to fatal liver diseases. However, it remains quite challenging because conventional CT can only identify the difference in density instead of X-ray attenuation characteristics. Spectral CT can generate monochromatic imaging to specify X-ray attenuation characteristics of the scanned matter. Herein, an X-ray energy-dependent attenuation strategy originated from bismuth (Bi)-based nanoprobes (BiF<sub>3</sub> @PDA@HA) is proposed for the accurate diagnosis of liver fibrosis. Bi element in BiF<sub>3</sub> @PDA@HA can exhibit characteristic attenuation depending on different levels of X-ray energy via spectral CT, and that is challenging for conventional CT. In this study, selectively accumulating B"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Harnessing X-Ray Energy-Dependent Attenuation of Bismuth-Based Nanoprobes for Accurate Diagnosis of Liver Fibrosis."],"pmcid":["PMC8188217"],"funding_grant_id":["19JC1412002","2020M681397","19JC1412000","51725202","81671732","51872094","SKMR2020B01","BX20200245","2018YFA0107900"],"pubmed_authors":["Liu Y","Zhai S","Yao Z","Zhang J","Bu W","Jiang X","Wu S","Wang X","Zhou Y","Meng X","Wu Y","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Harnessing X-Ray Energy-Dependent Attenuation of Bismuth-Based Nanoprobes for Accurate Diagnosis of Liver Fibrosis.","description":"Timely detection of liver fibrosis by X-ray computed tomography (CT) can prevent its progression to fatal liver diseases. However, it remains quite challenging because conventional CT can only identify the difference in density instead of X-ray attenuation characteristics. Spectral CT can generate monochromatic imaging to specify X-ray attenuation characteristics of the scanned matter. Herein, an X-ray energy-dependent attenuation strategy originated from bismuth (Bi)-based nanoprobes (BiF<sub>3</sub> @PDA@HA) is proposed for the accurate diagnosis of liver fibrosis. Bi element in BiF<sub>3</sub> @PDA@HA can exhibit characteristic attenuation depending on different levels of X-ray energy via spectral CT, and that is challenging for conventional CT. In this study, selectively accumulating B","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-22T16:27:40.28Z","creation":"2022-02-10T14:44:09.783Z"},"accession":"S-EPMC8188217","cross_references":{"pubmed":["34105274"],"doi":["10.1002/advs.202002548"]}}