biostudies-literatureWu SKey Project of Shanghai Science and Technology CommissionNational Key R&D Program of ChinaShanghai Key Laboratory of Magnetic ResonanceNational Natural Science Foundation of ChinaNational Funds for Distinguished Young ScientistsChina Postdoctoral Science Foundatione2002548https://www.ebi.ac.uk/biostudies/studies/S-EPMC8188217biostudies-literatureUnknown8(11)Timely detection of liver fibrosis by X-ray computed tomography (CT) can prevent its progression to fatal liver diseases. However, it remains quite challenging because conventional CT can only identify the difference in density instead of X-ray attenuation characteristics. Spectral CT can generate monochromatic imaging to specify X-ray attenuation characteristics of the scanned matter. Herein, an X-ray energy-dependent attenuation strategy originated from bismuth (Bi)-based nanoprobes (BiF₃ @PDA@HA) is proposed for the accurate diagnosis of liver fibrosis. Bi element in BiF₃ @PDA@HA can exhibit characteristic attenuation depending on different levels of X-ray energy via spectral CT, and that is challenging for conventional CT. In this study, selectively accumulating BAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Harnessing X-Ray Energy-Dependent Attenuation of Bismuth-Based Nanoprobes for Accurate Diagnosis of Liver Fibrosis.PMC818821719JC14120022020M68139719JC1412000517252028167173251872094SKMR2020B01BX202002452018YFA0107900Liu YZhai SYao ZZhang JBu WJiang XWu SWang XZhou YMeng XWu YZhao XfalseHarnessing X-Ray Energy-Dependent Attenuation of Bismuth-Based Nanoprobes for Accurate Diagnosis of Liver Fibrosis.Timely detection of liver fibrosis by X-ray computed tomography (CT) can prevent its progression to fatal liver diseases. However, it remains quite challenging because conventional CT can only identify the difference in density instead of X-ray attenuation characteristics. Spectral CT can generate monochromatic imaging to specify X-ray attenuation characteristics of the scanned matter. Herein, an X-ray energy-dependent attenuation strategy originated from bismuth (Bi)-based nanoprobes (BiF₃ @PDA@HA) is proposed for the accurate diagnosis of liver fibrosis. Bi element in BiF₃ @PDA@HA can exhibit characteristic attenuation depending on different levels of X-ray energy via spectral CT, and that is challenging for conventional CT. In this study, selectively accumulating B2021-01-01T00:00:00Z2021 Jun2025-04-22T16:27:40.28Z2022-02-10T14:44:09.783ZS-EPMC81882173410527410.1002/advs.202002548