{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Y"],"funding":["Chinese Academy of Sciences","Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China","Youth Innovation Promotion Association of the Chinese Academy of Sciences"],"pagination":["7763-7769"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8188586"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(22)"],"pubmed_abstract":["The extraordinarily rapid growth of malignant tumors depends heavily on the glucose metabolism by the pathways of glycolysis and mitochondrial oxidative phosphorylation to generate adenosine 5'-triphosphate (ATP) for maintaining cell proliferation and tumor growth. This study reports a tumor chemical suffocation therapeutic strategy by concurrently suppressing both glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) <i>via</i> the co-deliveries of EDTA and rotenone into a glutathione (GSH)-overexpressed tumor microenvironment. EDTA is to block the glycolytic pathway through inhibiting the activity of glycolytic enzymes <i>via</i> the chelation of magnesium ion, a co-worker of glycolytic enzymes, despite the presence of Ca<sup>2+</sup>. Meanwhile rotenone is to inhibit the mitoc"],"journal":["Chemical science"],"pubmed_title":["Tumor chemical suffocation therapy by dual respiratory inhibitions."],"pmcid":["PMC8188586"],"funding_grant_id":["ZDBS-LY-SLH029","2019","No. 21835007","No. 52072394","19QA1410100"],"pubmed_authors":["Guo Y","Chen L","Ni D","Shi J","Xu Y","Hu P"],"additional_accession":[]},"is_claimable":false,"name":"Tumor chemical suffocation therapy by dual respiratory inhibitions.","description":"The extraordinarily rapid growth of malignant tumors depends heavily on the glucose metabolism by the pathways of glycolysis and mitochondrial oxidative phosphorylation to generate adenosine 5'-triphosphate (ATP) for maintaining cell proliferation and tumor growth. This study reports a tumor chemical suffocation therapeutic strategy by concurrently suppressing both glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) <i>via</i> the co-deliveries of EDTA and rotenone into a glutathione (GSH)-overexpressed tumor microenvironment. EDTA is to block the glycolytic pathway through inhibiting the activity of glycolytic enzymes <i>via</i> the chelation of magnesium ion, a co-worker of glycolytic enzymes, despite the presence of Ca<sup>2+</sup>. Meanwhile rotenone is to inhibit the mitoc","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-06-01T02:31:08.697Z","creation":"2025-06-01T02:31:08.697Z"},"accession":"S-EPMC8188586","cross_references":{"pubmed":["34168829"],"doi":["10.1039/d1sc00929j"]}}