biostudies-literatureNosyk BMichael Smith Foundation for Health ResearchCanadian Institutes for Health Researche048353https://www.ebi.ac.uk/biostudies/studies/S-EPMC8190984biostudies-literatureUnknown11(6)<h4>Introduction</h4>The COVID-19 pandemic was preceded by an ongoing overdose crisis and linked to escalating drug overdose deaths in British Columbia (BC). At the outset of these dual public health emergencies, the BC government announced interim Risk Mitigation Guidance (RMG) that permitted prescribing medication alternatives to substances, including opioids, alcohol, stimulants and benzodiazepines, an intervention sometimes referred to as 'safe supply'. This protocol outlines the approach for a study of the implementation of RMG and its impacts on COVID-19 infection, drug-related and systemic harms, continuity of care for people with substance use disorder (SUD), as well as their behavioural, psychosocial and well-being outcomes.<h4>Methods and analysis</h4>We conducted a parallel mixeBMJ openEvaluation of risk mitigation measures for people with substance use disorders to address the dual public health crises of COVID-19 and overdose in British Columbia: a mixed-method study protocol.PMC819098418951172671Slaunwhite ABarker BHongdilokkul NZhao BLock KThomson EBeck-McGreevy PPauly BCard KGPalis HMin JEUrbanoski KMeilleur LNosyk BBurmeister CfalseEvaluation of risk mitigation measures for people with substance use disorders to address the dual public health crises of COVID-19 and overdose in British Columbia: a mixed-method study protocol.<h4>Introduction</h4>The COVID-19 pandemic was preceded by an ongoing overdose crisis and linked to escalating drug overdose deaths in British Columbia (BC). At the outset of these dual public health emergencies, the BC government announced interim Risk Mitigation Guidance (RMG) that permitted prescribing medication alternatives to substances, including opioids, alcohol, stimulants and benzodiazepines, an intervention sometimes referred to as 'safe supply'. This protocol outlines the approach for a study of the implementation of RMG and its impacts on COVID-19 infection, drug-related and systemic harms, continuity of care for people with substance use disorder (SUD), as well as their behavioural, psychosocial and well-being outcomes.<h4>Methods and analysis</h4>We conducted a parallel mixe2021-01-01T00:00:00Z2021 Jun2026-05-09T08:36:53.821Z2025-06-01T02:32:22.879ZS-EPMC81909843410817010.1136/bmjopen-2020-048353