biostudies-literatureSingh MDepartment of Science and Technology5933https://www.ebi.ac.uk/biostudies/studies/S-EPMC8199148biostudies-literatureUnknown18(11)The present study attempted to investigate whether concerted contributions of significant risk variables, pro-inflammatory markers, and candidate genes translate into a predictive marker for knee osteoarthritis (KOA). The present study comprised 279 confirmed osteoarthritis patients (Kellgren and Lawrence scale >2) and 287 controls. Twenty SNPs within five genes (CRP, COL1A1, IL-6, VDR, and eNOS), four pro-inflammatory markers (interleukin-6 (IL-6), interleuin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and high sensitivity C-reactive protein (hsCRP)), along with significant risk variables were investigated. A receiver operating characteristic (ROC) curve was used to observe the predictive ability of the model for distinguishing patients with KOA. Multivariable logistic regressionInternational journal of environmental research and public healthMultifactorial Landscape Parses to Reveal a Predictive Model for Knee Osteoarthritis.PMC8199148SR/WOS-A/LS-532/2016Minhas JSMastana SDi Napoli MSingh MValecha SJuneja PKSingh PKumar NKhinda RSingh SKaur TfalseMultifactorial Landscape Parses to Reveal a Predictive Model for Knee Osteoarthritis.The present study attempted to investigate whether concerted contributions of significant risk variables, pro-inflammatory markers, and candidate genes translate into a predictive marker for knee osteoarthritis (KOA). The present study comprised 279 confirmed osteoarthritis patients (Kellgren and Lawrence scale >2) and 287 controls. Twenty SNPs within five genes (CRP, COL1A1, IL-6, VDR, and eNOS), four pro-inflammatory markers (interleukin-6 (IL-6), interleuin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and high sensitivity C-reactive protein (hsCRP)), along with significant risk variables were investigated. A receiver operating characteristic (ROC) curve was used to observe the predictive ability of the model for distinguishing patients with KOA. Multivariable logistic regression2021-01-01T00:00:00Z2021 May2025-05-29T19:01:12.959Z2022-02-10T14:37:57.035ZS-EPMC81991483407313210.3390/ijerph18115933