{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Wang IK"],"pubmed_abstract":["The aim of the present study was to evaluate whether probiotic administration could slow declining renal function. C57BL/6 mice (6-8 weeks of age, male) were fed a diet supplemented with adenine to induce chronic kidney disease (CKD). The experimental groups were additionally supplemented with 10<sup>9</sup> colony-forming units (CFU)/day (high-dose) and 10<sup>7</sup> CFU/day (low-dose) probiotics containing <i>Lactobacillus acidophilus</i> (TYCA06), <i>Bifidobacterium longum</i> subspecies <i>infantis</i> (BLI-02), and <i>B. bifidum</i> (VDD088). Renal function and histology were examined. Patients with stage 3-5 CKD and not on dialysis were recruited from July 2017 to January 2019. Two capsules of probiotics containing 2.5 × 10<sup>9</sup> CFU with the same composition were administered"],"journal":["Frontiers in nutrition"],"pagination":["661794"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8200566"],"repository":["biostudies-literature"],"pubmed_title":["Effect of a Probiotic Combination in an Experimental Mouse Model and Clinical Patients With Chronic Kidney Disease: A Pilot Study."],"pmcid":["PMC8200566"],"pubmed_authors":["Ho HH","Lin HC","Kuo YL","Huang YY","Yen TH","Kuo YW","Li CY","Wang JY","Wang IK","Hsieh PS"],"additional_accession":[]},"is_claimable":false,"name":"Effect of a Probiotic Combination in an Experimental Mouse Model and Clinical Patients With Chronic Kidney Disease: A Pilot Study.","description":"The aim of the present study was to evaluate whether probiotic administration could slow declining renal function. C57BL/6 mice (6-8 weeks of age, male) were fed a diet supplemented with adenine to induce chronic kidney disease (CKD). The experimental groups were additionally supplemented with 10<sup>9</sup> colony-forming units (CFU)/day (high-dose) and 10<sup>7</sup> CFU/day (low-dose) probiotics containing <i>Lactobacillus acidophilus</i> (TYCA06), <i>Bifidobacterium longum</i> subspecies <i>infantis</i> (BLI-02), and <i>B. bifidum</i> (VDD088). Renal function and histology were examined. Patients with stage 3-5 CKD and not on dialysis were recruited from July 2017 to January 2019. Two capsules of probiotics containing 2.5 × 10<sup>9</sup> CFU with the same composition were administered","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T10:49:43.744Z","creation":"2022-02-10T15:21:18.715Z"},"accession":"S-EPMC8200566","cross_references":{"pubmed":["34136518"],"doi":["10.3389/fnut.2021.661794"]}}