biostudies-literatureUnknown8Wang IKThe aim of the present study was to evaluate whether probiotic administration could slow declining renal function. C57BL/6 mice (6-8 weeks of age, male) were fed a diet supplemented with adenine to induce chronic kidney disease (CKD). The experimental groups were additionally supplemented with 10⁹ colony-forming units (CFU)/day (high-dose) and 10⁷ CFU/day (low-dose) probiotics containing <i>Lactobacillus acidophilus</i> (TYCA06), <i>Bifidobacterium longum</i> subspecies <i>infantis</i> (BLI-02), and <i>B. bifidum</i> (VDD088). Renal function and histology were examined. Patients with stage 3-5 CKD and not on dialysis were recruited from July 2017 to January 2019. Two capsules of probiotics containing 2.5 × 10⁹ CFU with the same composition were administeredFrontiers in nutrition661794https://www.ebi.ac.uk/biostudies/studies/S-EPMC8200566biostudies-literatureEffect of a Probiotic Combination in an Experimental Mouse Model and Clinical Patients With Chronic Kidney Disease: A Pilot Study.PMC8200566Ho HHLin HCKuo YLHuang YYYen THKuo YWLi CYWang JYWang IKHsieh PSfalseEffect of a Probiotic Combination in an Experimental Mouse Model and Clinical Patients With Chronic Kidney Disease: A Pilot Study.The aim of the present study was to evaluate whether probiotic administration could slow declining renal function. C57BL/6 mice (6-8 weeks of age, male) were fed a diet supplemented with adenine to induce chronic kidney disease (CKD). The experimental groups were additionally supplemented with 10⁹ colony-forming units (CFU)/day (high-dose) and 10⁷ CFU/day (low-dose) probiotics containing <i>Lactobacillus acidophilus</i> (TYCA06), <i>Bifidobacterium longum</i> subspecies <i>infantis</i> (BLI-02), and <i>B. bifidum</i> (VDD088). Renal function and histology were examined. Patients with stage 3-5 CKD and not on dialysis were recruited from July 2017 to January 2019. Two capsules of probiotics containing 2.5 × 10⁹ CFU with the same composition were administered2021-01-01T00:00:00Z20212025-04-04T10:49:43.744Z2022-02-10T15:21:18.715ZS-EPMC82005663413651810.3389/fnut.2021.661794