{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(2)"],"submitter":["Sun X"],"pubmed_abstract":["O-linked glycosylation (<i>O</i>-glycosylation) and N-linked glycosylation (<i>N</i>-glycosylation) are the two most important forms of protein glycosylation, which is an important post-translational modification. The regulation of protein function involves numerous mechanisms, among which protein glycosylation is one of the most important. Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (<i>C1GALT1</i>) serves an important role in the regulation of <i>O</i>-glycosylation and is an essential enzyme for synthesizing the core 1 structure of mucin-type O-glycans. Furthermore, <i>C1GALT1</i> serves a vital role in a number of biological functions, such as angiogenesis, platelet production and kidney development. Impaired <i>C1GALT1</i> expression activity has bee"],"journal":["Oncology letters"],"pagination":["589"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8200938"],"repository":["biostudies-literature"],"pubmed_title":["C1GALT1 in health and disease."],"pmcid":["PMC8200938"],"pubmed_authors":["Zhan M","Sun X","Meng X","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"C1GALT1 in health and disease.","description":"O-linked glycosylation (<i>O</i>-glycosylation) and N-linked glycosylation (<i>N</i>-glycosylation) are the two most important forms of protein glycosylation, which is an important post-translational modification. The regulation of protein function involves numerous mechanisms, among which protein glycosylation is one of the most important. Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (<i>C1GALT1</i>) serves an important role in the regulation of <i>O</i>-glycosylation and is an essential enzyme for synthesizing the core 1 structure of mucin-type O-glycans. Furthermore, <i>C1GALT1</i> serves a vital role in a number of biological functions, such as angiogenesis, platelet production and kidney development. Impaired <i>C1GALT1</i> expression activity has bee","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T13:23:01.743Z","creation":"2022-02-10T15:48:32.377Z"},"accession":"S-EPMC8200938","cross_references":{"pubmed":["34149900"],"doi":["10.3892/ol.2021.12850"]}}