biostudies-literatureUnknown22(2)Sun XO-linked glycosylation (<i>O</i>-glycosylation) and N-linked glycosylation (<i>N</i>-glycosylation) are the two most important forms of protein glycosylation, which is an important post-translational modification. The regulation of protein function involves numerous mechanisms, among which protein glycosylation is one of the most important. Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (<i>C1GALT1</i>) serves an important role in the regulation of <i>O</i>-glycosylation and is an essential enzyme for synthesizing the core 1 structure of mucin-type O-glycans. Furthermore, <i>C1GALT1</i> serves a vital role in a number of biological functions, such as angiogenesis, platelet production and kidney development. Impaired <i>C1GALT1</i> expression activity has beeOncology letters589https://www.ebi.ac.uk/biostudies/studies/S-EPMC8200938biostudies-literatureC1GALT1 in health and disease.PMC8200938Zhan MSun XMeng XLiu WfalseC1GALT1 in health and disease.O-linked glycosylation (<i>O</i>-glycosylation) and N-linked glycosylation (<i>N</i>-glycosylation) are the two most important forms of protein glycosylation, which is an important post-translational modification. The regulation of protein function involves numerous mechanisms, among which protein glycosylation is one of the most important. Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (<i>C1GALT1</i>) serves an important role in the regulation of <i>O</i>-glycosylation and is an essential enzyme for synthesizing the core 1 structure of mucin-type O-glycans. Furthermore, <i>C1GALT1</i> serves a vital role in a number of biological functions, such as angiogenesis, platelet production and kidney development. Impaired <i>C1GALT1</i> expression activity has bee2021-01-01T00:00:00Z2021 Aug2025-04-04T13:23:01.743Z2022-02-10T15:48:32.377ZS-EPMC82009383414990010.3892/ol.2021.12850