{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Newsome RC"],"funding":["NCATS NIH HHS","UF Health Cancer Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript"],"pagination":["1-15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8205023"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["To investigate the relationship between intestinal microbiota and SARS-CoV-2-mediated pathogenicity in a United States, majority African American cohort. We prospectively collected fecal samples from 50 SARS-CoV-2 infected patients, 9 SARS-CoV-2 recovered patients, and 34 uninfected subjects seen by the hospital with unrelated respiratory medical conditions (controls). 16S rRNA sequencing and qPCR analysis was performed on fecal DNA/RNA. The fecal microbial composition was found to be significantly different between SARS-CoV-2 patients and controls (PERMANOVA FDR-<i>P</i> = .004), independent of antibiotic exposure. <i>Peptoniphilus, Corynebacterium</i> and <i>Campylobacter</i> were identified as the three most significantly enriched genera in COVID-19 patients compared to controls. Active"],"journal":["Gut microbes"],"pubmed_title":["The gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort."],"pmcid":["PMC8205023"],"funding_grant_id":["UL1 TR001427","TL1 TR001428"],"pubmed_authors":["Abraham GE","Gharaibeh RZ","Jobin C","Gauthier J","Sloan M","Newsome RC","Wilson KJ","Senitko M","Parker A","Pride Y","Laird H","Robinson TO","Christian T","Williams HB","Owings A","Hernandez MC","Glover SC","Hasan M"],"additional_accession":[]},"is_claimable":false,"name":"The gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort.","description":"To investigate the relationship between intestinal microbiota and SARS-CoV-2-mediated pathogenicity in a United States, majority African American cohort. We prospectively collected fecal samples from 50 SARS-CoV-2 infected patients, 9 SARS-CoV-2 recovered patients, and 34 uninfected subjects seen by the hospital with unrelated respiratory medical conditions (controls). 16S rRNA sequencing and qPCR analysis was performed on fecal DNA/RNA. The fecal microbial composition was found to be significantly different between SARS-CoV-2 patients and controls (PERMANOVA FDR-<i>P</i> = .004), independent of antibiotic exposure. <i>Peptoniphilus, Corynebacterium</i> and <i>Campylobacter</i> were identified as the three most significantly enriched genera in COVID-19 patients compared to controls. Active","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan-Dec","modification":"2026-05-01T03:17:05.83Z","creation":"2022-02-10T17:36:44.028Z"},"accession":"S-EPMC8205023","cross_references":{"pubmed":["34100340"],"doi":["10.1080/19490976.2021.1926840"]}}