biostudies-literatureNewsome RCNCATS NIH HHSUF Health Cancer Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript1-15https://www.ebi.ac.uk/biostudies/studies/S-EPMC8205023biostudies-literatureUnknown13(1)To investigate the relationship between intestinal microbiota and SARS-CoV-2-mediated pathogenicity in a United States, majority African American cohort. We prospectively collected fecal samples from 50 SARS-CoV-2 infected patients, 9 SARS-CoV-2 recovered patients, and 34 uninfected subjects seen by the hospital with unrelated respiratory medical conditions (controls). 16S rRNA sequencing and qPCR analysis was performed on fecal DNA/RNA. The fecal microbial composition was found to be significantly different between SARS-CoV-2 patients and controls (PERMANOVA FDR-<i>P</i> = .004), independent of antibiotic exposure. <i>Peptoniphilus, Corynebacterium</i> and <i>Campylobacter</i> were identified as the three most significantly enriched genera in COVID-19 patients compared to controls. ActiveGut microbesThe gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort.PMC8205023UL1 TR001427TL1 TR001428Abraham GEGharaibeh RZJobin CGauthier JSloan MNewsome RCWilson KJSenitko MParker APride YLaird HRobinson TOChristian TWilliams HBOwings AHernandez MCGlover SCHasan MfalseThe gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort.To investigate the relationship between intestinal microbiota and SARS-CoV-2-mediated pathogenicity in a United States, majority African American cohort. We prospectively collected fecal samples from 50 SARS-CoV-2 infected patients, 9 SARS-CoV-2 recovered patients, and 34 uninfected subjects seen by the hospital with unrelated respiratory medical conditions (controls). 16S rRNA sequencing and qPCR analysis was performed on fecal DNA/RNA. The fecal microbial composition was found to be significantly different between SARS-CoV-2 patients and controls (PERMANOVA FDR-<i>P</i> = .004), independent of antibiotic exposure. <i>Peptoniphilus, Corynebacterium</i> and <i>Campylobacter</i> were identified as the three most significantly enriched genera in COVID-19 patients compared to controls. Active2021-01-01T00:00:00Z2021 Jan-Dec2026-05-01T03:17:05.83Z2022-02-10T17:36:44.028ZS-EPMC82050233410034010.1080/19490976.2021.1926840