biostudies-literatureNogueira RGNINDS NIH HHSe2824-e2838https://www.ebi.ac.uk/biostudies/studies/S-EPMC8205458biostudies-literatureUnknown96(23)<h4>Objective</h4>To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods.<h4>Methods</h4>We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.<h4>Results</h4>There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, <i>p</i> < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 1NeurologyGlobal Impact of COVID-19 on Stroke Care and IV Thrombolysis.PMC8205458T32 NS061779Enzinger CDrenck NMultani SSRodrigues MKargiotis OWatanabe DRost NKhawaja AMFibrich PKristoffersen ESDemeestere JYuan ZYamazaki HLinares GAlhazzani AOndze BChaudry SABernava GFarhoudi MNovak JWan Zaidi WAChaturvedi SNovak ATham CHIbrahim ABAbdalkader MLobjanidze NKaushal RBandini FAlmeida MSHuang DYLuchowski PHashimoto HMacdougall LTian LSui YLiebeskind DCardoso FBKhinikadze MMenecie THuded VKlecka Lde Lecinana MALinfante IBrereton CJovin TGvan den Wijngaard IDembo TSramek MYaria JCatanese LKaczorowski RZaidat OONavia VYoung CJLee JSSaric MSSienkiewicz-Jarosz HNunes APHassan FDe Blauwe SRezek RMalhotra KSathya AMako MPatino MRSharma MLemmens REker OAltschul DDan MMansour OYSangalli DRingleb PAThomalla GNguyen THKanamaru TTuran TNKhandelwal PKaliaev ASunmonu TAGubeladze TBlanco ANguyen TNYaghi SNguyen TQDejesus Melgarejo Farina DETang SCMagalhaes PSCSivan Hoffmann RNtaios GKrarup Christensen HAlmeida Toro JMMustafa WTayal AMa AAlexiev FPortillo Rivera LISVIN COVID-19 Global Stroke RegistryKrejstova GFudala MBrehm ARoushdy TDevlin TGLiu GHussain SIDiaz Escobar LFKazmierski RFonseca LSalazar DGandhi DShah RNeumann JRosenkranz MHao YKram PChugh CHoroch-Lyszczarek ECaparros FCosta Rebello LPfeifer FVoetsch BSangha NSPerez-Sanchez SPeres RNwazor EOAyo-Martin OKlivenyi PUsman FSMantilla Barbosa DKGongora-Rivera FHokmabadi ESKrishnan KPalaiodimou LSobolova HKarpowic IDesai KPico FCastonguay AAlabi TOLiang CWNogueira RGSagris DMohammed HHSkoda OYoshida TSkoda MSingh AField TReznik AHelenius JGrigoryan MFukuda HMittal MSedghi AIbrahim KAFrankel MAref HMMalik AMTakenobu YSchmidt HCardozo Villamayor AOzretic DSiepmann TShokri HMMarto JPChung LWVenketasubramanian NUyttenboogaart MAlexandrov AWBrzezanski HKlingenberg Iversen HMichel PLNgwende GWHill MDLesaine ESakai NAlsbrook DTsai JPGattringer TKoyfman FMin JMiyashita FFrisullo GVarrone Giacomini LTarkanyi GRaz EDemchuk AMBedekovic MRTola Arribas MABalaguera OShimizu HSzeder VCruz Culebras AGroppa SKoutny MPujol Lereis VAMistry EALeahu PImam YZWisniewska ATsiskaridze AGwaunza LYan YAlvarado-Ortiz AJSugimura YKondybayeva ABasri HBNevsimalova MFaizullina KAl-Jehani HMont'alverne FMatsumaru YMayza MTeleb MBach ILee VHMackey ASakaguchi MJohn SNhu Pham TProchazka PJurak LKwan JAbraham MPiotin MPikula AHlavacova HVibo RHankey GJYamada TAdebayo PBYamada SMartins RTEdgell RSahathevan RZetola VFOhara NBadruddin ARamakrishnan PYagita YPierre Rutgers MSzapary LNalleballe KArenillas JFBarboza MAKarlinski MSaposnik GFalup-Pecurariu CRanta ABayona HZhao WMartins SOAntsov KWienecke TSiegler JENguyen HHScott CALongo ALRenieri LLeung TWBai FKleindorfer DOJura RGupta RWahab KHanelova KAykac OYip SLee SBGralla JAguiar de Sousa DBarrientos Iman DMStrasser SLFaucheux JMCzap ALMasoud HDharmadhikari SShuaib ATejedor EDAmaya PFRTran ADZhanuzakov MPirson AKhoury NNVolny OLara ODe Raedt SCorredor AQiu ZKim BSMechtouff LAdami ASobolewski PAi ZSheth SAHwang YLi GChurojana AEtherton MMehta BPSzabo KChen CHKhosravani HRuland SLi WTodo KVachova MSugiura YKandyba DPop RYamagami HLoochtan ALuraschi AMoon JKorv JBila Lamou EGChoe HBudincevic HMachi PArabambi BRivera Ordonez CEAkil EButt ABiller JShoamanesh AMontaner JVanacker PBrola WFiksa JTokuda NStrambo DRahangdale RHYperzeele LValler LKrastev GNguyen CBLuo JOrtega-Gutierrez SOlavarria VVHolmstedt CATan WYPinho E Melo TZhang JQureshi MMRiahi ADZhang HOzdemir AOAhdab RFarooqui MHaynes JYazawa YRodriguez Vasquez AHaussen DCNakahara ITopinka ZDoijiri RTenora DAziz ZARomero JRFischer UZelaya Zarza AJSimmons MMenon BMikulik RTsivgoulis GKleinig TLutsep HLBellante FStarosciak AKAl Hashmi AMRogoziewicz MLeung LYTruelsen TCGross-Paju KSohn SITedim Cruz VFerreira PBaek JHMora Cuervo DLLigot NKamenova SFrei DGiray SCo COSeo JHMohammaden MHSilver BLavados PMFryze WYahya NWHuang WSeo KDCordonnier CKono RVanhooren GTerasaki TMamauag MJNovarro-Escudero NCalabresi PMcDermott MCernik DWu BNagel SWen HHucika ZPineda-Franks MCShang XAkhtar NHassan AEHorev AToomsoo TRahman AYamamoto NPark HKiller-Oberpfalzer MLooi IDoss VTSylaja PNYamamoto RSassi SBCindric IBarazangi NCzlonkowska ARodriguez Kadota LHair CHlinovsky DPandian JDSahakyan DDe Deus Silva LPsychogios MNConforto ARothstein AMale SNovakovic-White RSakelarova TElbassiouny AUwatoko TSarfo FSChoi JHWiszniewska MBanerjee SYuan-Hao Wu TZha AMOliveira Lima FMiyake KSimonsen CZYavagal DRThijs VBarrientos JDVaclavik DZi WNahab FDuan ZSonoda KLe Vu HDusart ARouanet FMorris JGShimbo JCampbell BTomazini Martins RfalseGlobal Impact of COVID-19 on Stroke Care and IV Thrombolysis.<h4>Objective</h4>To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods.<h4>Methods</h4>We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.<h4>Results</h4>There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, <i>p</i> < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 12021-01-01T00:00:00Z2021 Jun2025-04-04T22:33:42.524Z2025-02-19T03:23:54.99ZS-EPMC82054583376699710.1212/WNL.000000000001188510.1212/wnl.0000000000011885