{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhuo J"],"funding":["National Institute of Neurological Disorders and Stroke","NCRR NIH HHS","NINDS NIH HHS","Department of Defense"],"pagination":["725-733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8207827"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(6)"],"pubmed_abstract":["<b>Objective</b>: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome.<b>Methods</b>: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life.<b>Res"],"journal":["Brain injury"],"pubmed_title":["Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury."],"pmcid":["PMC8207827"],"funding_grant_id":["W81XWH-08-1-0725","5R01NS10550","R03 NS088014","R01 NS105503","S10 RR019214"],"pubmed_authors":["Jiang L","Gullapalli RP","Prince JL","Zhuo J","Roys S","Chen H","Shanmuganathan K","Sours Rhodes C","Badjatia N"],"additional_accession":[]},"is_claimable":false,"name":"Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.","description":"<b>Objective</b>: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome.<b>Methods</b>: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life.<b>Res","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-05T10:04:03.867Z","creation":"2025-04-05T10:04:03.867Z"},"accession":"S-EPMC8207827","cross_references":{"pubmed":["33822686"],"doi":["10.1080/02699052.2021.1906445"]}}