biostudies-literatureZhuo JNational Institute of Neurological Disorders and StrokeNCRR NIH HHSNINDS NIH HHSDepartment of Defense725-733https://www.ebi.ac.uk/biostudies/studies/S-EPMC8207827biostudies-literatureUnknown35(6)<b>Objective</b>: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome.<b>Methods</b>: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life.<b>ResBrain injuryEarly Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.PMC8207827W81XWH-08-1-07255R01NS10550R03 NS088014R01 NS105503S10 RR019214Jiang LGullapalli RPPrince JLZhuo JRoys SChen HShanmuganathan KSours Rhodes CBadjatia NfalseEarly Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.<b>Objective</b>: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome.<b>Methods</b>: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life.<b>Res2021-01-01T00:00:00Z2021 May2025-04-05T10:04:03.867Z2025-04-05T10:04:03.867ZS-EPMC82078273382268610.1080/02699052.2021.1906445