{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leung YKS"],"funding":["Swiss National Science Foundation","Clinical Research Priority Program of the University of Zurich for the CRPP ‘Precision medicine for bacterial infections’"],"pagination":["dlab041"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8209986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["<h4>Background</h4>Optimal timing for rifampicin combination therapy in patients with staphylococcal vascular graft/endograft infection (S-VGEI) is unknown. Experts recommend adding rifampicin after lowering bacterial load by surgery and wound closure.<h4>Objectives</h4>To assess predictors of rifampicin resistance among staphylococci isolated from patients in the Vascular Graft Infection Cohort Study.<h4>Methods</h4>We included prospective patients with S-VGEI diagnosis from 1 January 2002 to 30 June 2020. We retrospectively assessed determinants of rifampicin resistance using exact logistic regression and described survival with Kaplan-Meier curves.<h4>Results</h4>We analysed 513 <i>Staphylococcus</i> spp. among 143 predominantly male (82%) patients with a median age of 68 years (IQR 60-"],"journal":["JAC-antimicrobial resistance"],"pubmed_title":["Open wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections."],"pmcid":["PMC8209986"],"funding_grant_id":["320030","320030_184918/1","184918"],"pubmed_authors":["Zimmermann A","Zbinden R","Ledergerber B","Brugger SD","Leung YKS","Zinkernagel AS","Mestres CA","Eberhard N","Vascular Graft Cohort Study","Rancic Z","Hasse B"],"additional_accession":[]},"is_claimable":false,"name":"Open wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections.","description":"<h4>Background</h4>Optimal timing for rifampicin combination therapy in patients with staphylococcal vascular graft/endograft infection (S-VGEI) is unknown. Experts recommend adding rifampicin after lowering bacterial load by surgery and wound closure.<h4>Objectives</h4>To assess predictors of rifampicin resistance among staphylococci isolated from patients in the Vascular Graft Infection Cohort Study.<h4>Methods</h4>We included prospective patients with S-VGEI diagnosis from 1 January 2002 to 30 June 2020. We retrospectively assessed determinants of rifampicin resistance using exact logistic regression and described survival with Kaplan-Meier curves.<h4>Results</h4>We analysed 513 <i>Staphylococcus</i> spp. among 143 predominantly male (82%) patients with a median age of 68 years (IQR 60-","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-18T19:15:25.713Z","creation":"2022-02-10T18:01:00.829Z"},"accession":"S-EPMC8209986","cross_references":{"pubmed":["34223108"],"doi":["10.1093/jacamr/dlab041"]}}