biostudies-literatureLeung YKSSwiss National Science FoundationClinical Research Priority Program of the University of Zurich for the CRPP ‘Precision medicine for bacterial infections’dlab041https://www.ebi.ac.uk/biostudies/studies/S-EPMC8209986biostudies-literatureUnknown3(1)<h4>Background</h4>Optimal timing for rifampicin combination therapy in patients with staphylococcal vascular graft/endograft infection (S-VGEI) is unknown. Experts recommend adding rifampicin after lowering bacterial load by surgery and wound closure.<h4>Objectives</h4>To assess predictors of rifampicin resistance among staphylococci isolated from patients in the Vascular Graft Infection Cohort Study.<h4>Methods</h4>We included prospective patients with S-VGEI diagnosis from 1 January 2002 to 30 June 2020. We retrospectively assessed determinants of rifampicin resistance using exact logistic regression and described survival with Kaplan-Meier curves.<h4>Results</h4>We analysed 513 <i>Staphylococcus</i> spp. among 143 predominantly male (82%) patients with a median age of 68 years (IQR 60-JAC-antimicrobial resistanceOpen wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections.PMC8209986320030320030_184918/1184918Zimmermann AZbinden RLedergerber BBrugger SDLeung YKSZinkernagel ASMestres CAEberhard NVascular Graft Cohort StudyRancic ZHasse BfalseOpen wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections.<h4>Background</h4>Optimal timing for rifampicin combination therapy in patients with staphylococcal vascular graft/endograft infection (S-VGEI) is unknown. Experts recommend adding rifampicin after lowering bacterial load by surgery and wound closure.<h4>Objectives</h4>To assess predictors of rifampicin resistance among staphylococci isolated from patients in the Vascular Graft Infection Cohort Study.<h4>Methods</h4>We included prospective patients with S-VGEI diagnosis from 1 January 2002 to 30 June 2020. We retrospectively assessed determinants of rifampicin resistance using exact logistic regression and described survival with Kaplan-Meier curves.<h4>Results</h4>We analysed 513 <i>Staphylococcus</i> spp. among 143 predominantly male (82%) patients with a median age of 68 years (IQR 60-2021-01-01T00:00:00Z2021 Mar2025-04-18T19:15:25.713Z2022-02-10T18:01:00.829ZS-EPMC82099863422310810.1093/jacamr/dlab041