{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Getanda P"],"funding":["Medical Research Council Unit The Gambia (MRCG) PhD fellowship","Medical Research Council","UK Medical Research Council and the UK Department for International Development (DFID) under the MRC/DFID Concordat"],"pagination":["dlaa128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8210243"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["<h4>Objectives</h4>To evaluate the impact of one oral dose of intrapartum azithromycin (2 g) on the carriage and antibiotic resistance of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in the nasopharynx, breast milk and vaginal swabs of mothers and <i>K. pneumoniae</i> in the nasopharynx of their newborns.<h4>Methods</h4>We performed a post hoc analysis of a double-blind, placebo-controlled randomized-trial (ratio 1:1) conducted in The Gambia. Breast milk (BM) and vaginal swabs (VS) from mothers and nasopharyngeal swabs (NPS) from mother-newborn pairs were collected at different timepoints during the 4 week follow-up. Samples were processed using standard microbiological procedures. For BM and NPS post-intervention results were combined for analysis.<h4>Results</h4>In the origin"],"journal":["JAC-antimicrobial resistance"],"pubmed_title":["Short-term increase in the carriage of azithromycin-resistant <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in mothers and their newborns following intra-partum azithromycin: a post hoc analysis of a double-blind randomized trial."],"pmcid":["PMC8210243"],"funding_grant_id":["MR/J010391/1","MC_EX_MR/J010391/1"],"pubmed_authors":["Jagne-Cox I","Bojang A","Usuf E","Camara B","Roca A","Bottomley C","Getanda P","Howden BP","D'Alessandro U"],"additional_accession":[]},"is_claimable":false,"name":"Short-term increase in the carriage of azithromycin-resistant <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in mothers and their newborns following intra-partum azithromycin: a post hoc analysis of a double-blind randomized trial.","description":"<h4>Objectives</h4>To evaluate the impact of one oral dose of intrapartum azithromycin (2 g) on the carriage and antibiotic resistance of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in the nasopharynx, breast milk and vaginal swabs of mothers and <i>K. pneumoniae</i> in the nasopharynx of their newborns.<h4>Methods</h4>We performed a post hoc analysis of a double-blind, placebo-controlled randomized-trial (ratio 1:1) conducted in The Gambia. Breast milk (BM) and vaginal swabs (VS) from mothers and nasopharyngeal swabs (NPS) from mother-newborn pairs were collected at different timepoints during the 4 week follow-up. Samples were processed using standard microbiological procedures. For BM and NPS post-intervention results were combined for analysis.<h4>Results</h4>In the origin","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-20T00:15:49.78Z","creation":"2022-02-10T18:27:14.28Z"},"accession":"S-EPMC8210243","cross_references":{"pubmed":["34223077"],"doi":["10.1093/jacamr/dlaa128"]}}