biostudies-literatureGetanda PMedical Research Council Unit The Gambia (MRCG) PhD fellowshipMedical Research CouncilUK Medical Research Council and the UK Department for International Development (DFID) under the MRC/DFID Concordatdlaa128https://www.ebi.ac.uk/biostudies/studies/S-EPMC8210243biostudies-literatureUnknown3(1)<h4>Objectives</h4>To evaluate the impact of one oral dose of intrapartum azithromycin (2 g) on the carriage and antibiotic resistance of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in the nasopharynx, breast milk and vaginal swabs of mothers and <i>K. pneumoniae</i> in the nasopharynx of their newborns.<h4>Methods</h4>We performed a post hoc analysis of a double-blind, placebo-controlled randomized-trial (ratio 1:1) conducted in The Gambia. Breast milk (BM) and vaginal swabs (VS) from mothers and nasopharyngeal swabs (NPS) from mother-newborn pairs were collected at different timepoints during the 4 week follow-up. Samples were processed using standard microbiological procedures. For BM and NPS post-intervention results were combined for analysis.<h4>Results</h4>In the originJAC-antimicrobial resistanceShort-term increase in the carriage of azithromycin-resistant <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in mothers and their newborns following intra-partum azithromycin: a post hoc analysis of a double-blind randomized trial.PMC8210243MR/J010391/1MC_EX_MR/J010391/1Jagne-Cox IBojang AUsuf ECamara BRoca ABottomley CGetanda PHowden BPD'Alessandro UfalseShort-term increase in the carriage of azithromycin-resistant <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in mothers and their newborns following intra-partum azithromycin: a post hoc analysis of a double-blind randomized trial.<h4>Objectives</h4>To evaluate the impact of one oral dose of intrapartum azithromycin (2 g) on the carriage and antibiotic resistance of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in the nasopharynx, breast milk and vaginal swabs of mothers and <i>K. pneumoniae</i> in the nasopharynx of their newborns.<h4>Methods</h4>We performed a post hoc analysis of a double-blind, placebo-controlled randomized-trial (ratio 1:1) conducted in The Gambia. Breast milk (BM) and vaginal swabs (VS) from mothers and nasopharyngeal swabs (NPS) from mother-newborn pairs were collected at different timepoints during the 4 week follow-up. Samples were processed using standard microbiological procedures. For BM and NPS post-intervention results were combined for analysis.<h4>Results</h4>In the origin2021-01-01T00:00:00Z2021 Mar2025-04-20T00:15:49.78Z2022-02-10T18:27:14.28ZS-EPMC82102433422307710.1093/jacamr/dlaa128