{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sadeghi MB"],"funding":["Zahedan University of Medical Sciences"],"pagination":["261-270"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8212291"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Purpose</h4>To investigate if single-nucleotide polymorphisms (SNPs) in the <i>NR1H2</i> gene encoding <i>LXRβ</i> contribute to the development of type-2 diabetes mellitus (T2DM) and whether genotypes of two <i>NR1H2</i> polymorphisms, rs28514894 and rs2303044, are associated with laboratory characteristics of T2DM patients.<h4>Method</h4>A total of 900 subjects (450 T2DM cases and 450 healthy subjects) of Iranian ancestry were genotyped for <i>NR1H2</i> polymorphisms via ARMS-PCR and PCR-RFLP techniques.<h4>Result</h4>Our findings showed a significant correlation between both polymorphisms and increased risk of T2DM. The haplotype analysis showed an association between the C A haplotype with enhanced risk of T2DM. In T2DM patients, the mean level of HbA1C and BUN significantly differ"],"journal":["Journal of diabetes and metabolic disorders"],"pubmed_title":["Significant association of <i>LXRβ (NR1H2)</i> polymorphisms (rs28514894, rs2303044) with type 2 diabetes mellitus and laboratory characteristics."],"pmcid":["PMC8212291"],"funding_grant_id":["9729"],"pubmed_authors":["Saravani R","Nakhaee A","Sadeghi MB","Sargazi S"],"additional_accession":[]},"is_claimable":false,"name":"Significant association of <i>LXRβ (NR1H2)</i> polymorphisms (rs28514894, rs2303044) with type 2 diabetes mellitus and laboratory characteristics.","description":"<h4>Purpose</h4>To investigate if single-nucleotide polymorphisms (SNPs) in the <i>NR1H2</i> gene encoding <i>LXRβ</i> contribute to the development of type-2 diabetes mellitus (T2DM) and whether genotypes of two <i>NR1H2</i> polymorphisms, rs28514894 and rs2303044, are associated with laboratory characteristics of T2DM patients.<h4>Method</h4>A total of 900 subjects (450 T2DM cases and 450 healthy subjects) of Iranian ancestry were genotyped for <i>NR1H2</i> polymorphisms via ARMS-PCR and PCR-RFLP techniques.<h4>Result</h4>Our findings showed a significant correlation between both polymorphisms and increased risk of T2DM. The haplotype analysis showed an association between the C A haplotype with enhanced risk of T2DM. In T2DM patients, the mean level of HbA1C and BUN significantly differ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-19T23:33:09.58Z","creation":"2022-02-11T16:06:54.558Z"},"accession":"S-EPMC8212291","cross_references":{"pubmed":["34178836"],"doi":["10.1007/s40200-021-00740-3"]}}