biostudies-literatureSadeghi MBZahedan University of Medical Sciences261-270https://www.ebi.ac.uk/biostudies/studies/S-EPMC8212291biostudies-literatureUnknown20(1)<h4>Purpose</h4>To investigate if single-nucleotide polymorphisms (SNPs) in the <i>NR1H2</i> gene encoding <i>LXRβ</i> contribute to the development of type-2 diabetes mellitus (T2DM) and whether genotypes of two <i>NR1H2</i> polymorphisms, rs28514894 and rs2303044, are associated with laboratory characteristics of T2DM patients.<h4>Method</h4>A total of 900 subjects (450 T2DM cases and 450 healthy subjects) of Iranian ancestry were genotyped for <i>NR1H2</i> polymorphisms via ARMS-PCR and PCR-RFLP techniques.<h4>Result</h4>Our findings showed a significant correlation between both polymorphisms and increased risk of T2DM. The haplotype analysis showed an association between the C A haplotype with enhanced risk of T2DM. In T2DM patients, the mean level of HbA1C and BUN significantly differJournal of diabetes and metabolic disordersSignificant association of <i>LXRβ (NR1H2)</i> polymorphisms (rs28514894, rs2303044) with type 2 diabetes mellitus and laboratory characteristics.PMC82122919729Saravani RNakhaee ASadeghi MBSargazi SfalseSignificant association of <i>LXRβ (NR1H2)</i> polymorphisms (rs28514894, rs2303044) with type 2 diabetes mellitus and laboratory characteristics.<h4>Purpose</h4>To investigate if single-nucleotide polymorphisms (SNPs) in the <i>NR1H2</i> gene encoding <i>LXRβ</i> contribute to the development of type-2 diabetes mellitus (T2DM) and whether genotypes of two <i>NR1H2</i> polymorphisms, rs28514894 and rs2303044, are associated with laboratory characteristics of T2DM patients.<h4>Method</h4>A total of 900 subjects (450 T2DM cases and 450 healthy subjects) of Iranian ancestry were genotyped for <i>NR1H2</i> polymorphisms via ARMS-PCR and PCR-RFLP techniques.<h4>Result</h4>Our findings showed a significant correlation between both polymorphisms and increased risk of T2DM. The haplotype analysis showed an association between the C A haplotype with enhanced risk of T2DM. In T2DM patients, the mean level of HbA1C and BUN significantly differ2021-01-01T00:00:00Z2021 Jun2025-04-19T23:33:09.58Z2022-02-11T16:06:54.558ZS-EPMC82122913417883610.1007/s40200-021-00740-3