{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hafeman DM"],"funding":["NIMH NIH HHS","National Institute of Mental Health"],"pagination":["463-473"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8213864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(5)"],"pubmed_abstract":["<h4>Objectives</h4>While adults with bipolar disorder (BD) often report symptoms starting in childhood, continuity of mania and/or hypomania (mania/hypomania) from childhood to adulthood has been questioned. Using longitudinal data from the Course and Outcome of Bipolar Youth (COBY) study, we assessed threshold mania/hypomania in young adults who manifested BD as youth.<h4>Methods</h4>COBY is a naturalistic, longitudinal study of 446 youth with BD (84% recruited from outpatient clinics), 7-17 years old at intake, and over 11 years of follow-up. Focusing on youth with BD-I/II (n = 297), we examined adult mania/hypomania risk (>18 years old; mean 7.9 years of follow-up) according to child (<13 years old) versus adolescent (13-17 years old) onset. We next used penalized regression to test dem"],"journal":["Bipolar disorders"],"pubmed_title":["Prospectively ascertained mania and hypomania among young adults with child- and adolescent-onset bipolar disorder."],"pmcid":["PMC8213864"],"funding_grant_id":["MH05977","R01 MH059977","K23 MH110421","R01 MH059929","R01 MH059691","MH059691","R01 MH112544","R01 MH112543","MH059929"],"pubmed_authors":["Diler RS","Ryan ND","Yen S","Hower H","Strober M","Birmaher B","Goldstein TR","Hunt JI","Hafeman DM","Goldstein BI","Liao F","Axelson DA","Gill MK","Weinstock LM","Merranko J","Keller MB"],"additional_accession":[]},"is_claimable":false,"name":"Prospectively ascertained mania and hypomania among young adults with child- and adolescent-onset bipolar disorder.","description":"<h4>Objectives</h4>While adults with bipolar disorder (BD) often report symptoms starting in childhood, continuity of mania and/or hypomania (mania/hypomania) from childhood to adulthood has been questioned. Using longitudinal data from the Course and Outcome of Bipolar Youth (COBY) study, we assessed threshold mania/hypomania in young adults who manifested BD as youth.<h4>Methods</h4>COBY is a naturalistic, longitudinal study of 446 youth with BD (84% recruited from outpatient clinics), 7-17 years old at intake, and over 11 years of follow-up. Focusing on youth with BD-I/II (n = 297), we examined adult mania/hypomania risk (>18 years old; mean 7.9 years of follow-up) according to child (<13 years old) versus adolescent (13-17 years old) onset. We next used penalized regression to test dem","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T21:25:09.33Z","creation":"2025-04-04T21:25:09.33Z"},"accession":"S-EPMC8213864","cross_references":{"pubmed":["33340226"],"doi":["10.1111/bdi.13034"]}}