biostudies-literatureHafeman DMNIMH NIH HHSNational Institute of Mental Health463-473https://www.ebi.ac.uk/biostudies/studies/S-EPMC8213864biostudies-literatureUnknown23(5)<h4>Objectives</h4>While adults with bipolar disorder (BD) often report symptoms starting in childhood, continuity of mania and/or hypomania (mania/hypomania) from childhood to adulthood has been questioned. Using longitudinal data from the Course and Outcome of Bipolar Youth (COBY) study, we assessed threshold mania/hypomania in young adults who manifested BD as youth.<h4>Methods</h4>COBY is a naturalistic, longitudinal study of 446 youth with BD (84% recruited from outpatient clinics), 7-17 years old at intake, and over 11 years of follow-up. Focusing on youth with BD-I/II (n = 297), we examined adult mania/hypomania risk (>18 years old; mean 7.9 years of follow-up) according to child (<13 years old) versus adolescent (13-17 years old) onset. We next used penalized regression to test demBipolar disordersProspectively ascertained mania and hypomania among young adults with child- and adolescent-onset bipolar disorder.PMC8213864MH05977R01 MH059977K23 MH110421R01 MH059929R01 MH059691MH059691R01 MH112544R01 MH112543MH059929Diler RSRyan NDYen SHower HStrober MBirmaher BGoldstein TRHunt JIHafeman DMGoldstein BILiao FAxelson DAGill MKWeinstock LMMerranko JKeller MBfalseProspectively ascertained mania and hypomania among young adults with child- and adolescent-onset bipolar disorder.<h4>Objectives</h4>While adults with bipolar disorder (BD) often report symptoms starting in childhood, continuity of mania and/or hypomania (mania/hypomania) from childhood to adulthood has been questioned. Using longitudinal data from the Course and Outcome of Bipolar Youth (COBY) study, we assessed threshold mania/hypomania in young adults who manifested BD as youth.<h4>Methods</h4>COBY is a naturalistic, longitudinal study of 446 youth with BD (84% recruited from outpatient clinics), 7-17 years old at intake, and over 11 years of follow-up. Focusing on youth with BD-I/II (n = 297), we examined adult mania/hypomania risk (>18 years old; mean 7.9 years of follow-up) according to child (<13 years old) versus adolescent (13-17 years old) onset. We next used penalized regression to test dem2021-01-01T00:00:00Z2021 Aug2025-04-04T21:25:09.33Z2025-04-04T21:25:09.33ZS-EPMC82138643334022610.1111/bdi.13034