{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee MJ"],"funding":["Korea Centers for Disease Control and Prevention"],"pagination":["870-879"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8216611"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(6)"],"pubmed_abstract":["<h4>Background and objectives</h4>Smoking is associated with vascular calcification and a higher risk of cardiovascular disease. In this study, we investigated the association of smoking dose and cessation with coronary artery calcification (CAC) in patients with CKD.<h4>Design, setting, participants, & measurements</h4>From a nationwide, prospective cohort of Korean patients with CKD, 1914 participants were included. Prevalent CAC was defined as an Agatston score >0, using computed tomography. CAC progression was defined as ≥30%/yr increase in Agatston score at the 4-year follow-up examination in patients with baseline CAC.<h4>Results</h4>Prevalent CAC was observed in 952 (50%) patients. Compared with never smokers, former smokers had a similar prevalence ratio for CAC, but current smokers had a 1.25-fold higher prevalence ratio (95% confidence interval [95% CI], 1.10 to 1.42). Among former smokers, a lower smoking load of <10 pack-years (prevalence ratio, 0.77; 95% CI, 0.65 to 0.90) and longer duration of smoking cessation (prevalence ratio for 10 to <20 years, 0.85; 95% CI, 0.73 to 0.98: prevalence ratio for ≥20 years, 0.83; 95% CI, 0.73 to 0.96) were associated with lower risk of prevalent CAC compared with current smoking. The prevalence ratios did not differ between never smoking and long-term cessation. However, short-term cessation with heavy smoking load was associated with a higher risk of prevalent CAC (prevalence ratio, 1.21; 95% CI, 1.03 to 1.40) compared with never smoking. CAC progression was observed in 111 (33%) patients with baseline CAC. Compared with never smokers, former smokers showed a similar risk of CAC progression, but current smokers had a higher risk (relative risk, 1.92; 95% CI, 1.30 to 2.86).<h4>Conclusions</h4>In CKD, former smoking with a lower smoking load and long-term cessation were associated with a lower risk of prevalent CAC than current smoking. CAC progression was more pronounced in current smokers."],"journal":["Clinical journal of the American Society of Nephrology : CJASN"],"pubmed_title":["Smoking Cessation and Coronary Artery Calcification in CKD."],"pmcid":["PMC8216611"],"funding_grant_id":["2011E3300300","2016E3300202","2016E3300200","2016E3300201","2013E3301602","2013E3301600","2019E320100","2013E3301601","2019E320101","2012E3301100"],"pubmed_authors":["Kim SW","Kang SW","Joo YS","Han SH","Oh KH","Ahn C","Park JT","Yoo TH","Chang TI","Choi KH","Chung W","Park SK","Kim YS","Lee MJ"],"additional_accession":[]},"is_claimable":false,"name":"Smoking Cessation and Coronary Artery Calcification in CKD.","description":"<h4>Background and objectives</h4>Smoking is associated with vascular calcification and a higher risk of cardiovascular disease. In this study, we investigated the association of smoking dose and cessation with coronary artery calcification (CAC) in patients with CKD.<h4>Design, setting, participants, & measurements</h4>From a nationwide, prospective cohort of Korean patients with CKD, 1914 participants were included. Prevalent CAC was defined as an Agatston score >0, using computed tomography. CAC progression was defined as ≥30%/yr increase in Agatston score at the 4-year follow-up examination in patients with baseline CAC.<h4>Results</h4>Prevalent CAC was observed in 952 (50%) patients. Compared with never smokers, former smokers had a similar prevalence ratio for CAC, but current smokers had a 1.25-fold higher prevalence ratio (95% confidence interval [95% CI], 1.10 to 1.42). Among former smokers, a lower smoking load of <10 pack-years (prevalence ratio, 0.77; 95% CI, 0.65 to 0.90) and longer duration of smoking cessation (prevalence ratio for 10 to <20 years, 0.85; 95% CI, 0.73 to 0.98: prevalence ratio for ≥20 years, 0.83; 95% CI, 0.73 to 0.96) were associated with lower risk of prevalent CAC compared with current smoking. The prevalence ratios did not differ between never smoking and long-term cessation. However, short-term cessation with heavy smoking load was associated with a higher risk of prevalent CAC (prevalence ratio, 1.21; 95% CI, 1.03 to 1.40) compared with never smoking. CAC progression was observed in 111 (33%) patients with baseline CAC. Compared with never smokers, former smokers showed a similar risk of CAC progression, but current smokers had a higher risk (relative risk, 1.92; 95% CI, 1.30 to 2.86).<h4>Conclusions</h4>In CKD, former smoking with a lower smoking load and long-term cessation were associated with a lower risk of prevalent CAC than current smoking. CAC progression was more pronounced in current smokers.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-09T03:07:43.356Z","creation":"2025-02-18T23:32:12.397Z"},"accession":"S-EPMC8216611","cross_references":{"pubmed":["33879501"],"doi":["10.2215/cjn.15751020","10.2215/CJN.15751020"]}}