{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang B"],"funding":["NIDDK NIH HHS","Burroughs Wellcome Fund","NCI NIH HHS","National Institutes of Health"],"pagination":["120-131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8217095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(1)"],"pubmed_abstract":["<h4>Background & aims</h4>Gain of function (GOF) mutations in the CTNNB1 gene are one of the most frequent genetic events in hepatocellular carcinoma (HCC). T-box transcription factor 3 (TBX3) is a liver-specific target of the Wnt/β-catenin pathway and thought to be an oncogene mediating activated β-catenin-driven HCC formation.<h4>Methods</h4>We evaluated the expression pattern of TBX3 in human HCC specimens. Tbx3 was conditionally knocked out in murine HCC models by hydrodynamic tail vein injection of Cre together with c-Met and ΔN90-β-catenin (c-Met/β-catenin) in Tbx3<sup>flox/flox</sup> mice. TBX3 was overexpressed in human HCC cell lines to investigate the functions of TBX3 in vitro.<h4>Results</h4>A bimodal expression pattern of TBX3 in human HCC samples was detected: high expression"],"journal":["Journal of hepatology"],"pubmed_title":["TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis."],"pmcid":["PMC8217095"],"funding_grant_id":["P30 DK026743","P30 DK120531","P30DK026743","R01 CA251155","R01 CA239251","R01CA239251","R01 CA250227","K08DK101603","R01CA204586","R01CA250227","K08 DK101603","R01 CA204586"],"pubmed_authors":["Xu M","Lin S","Wang B","Wang H","Zhou Y","Monga SP","Wang J","Ren C","Evert M","Liang B","Huang Z","Zhang Y","Chen Y","Chen X","Song X","Calvisi DF","Qian M"],"additional_accession":[]},"is_claimable":false,"name":"TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.","description":"<h4>Background & aims</h4>Gain of function (GOF) mutations in the CTNNB1 gene are one of the most frequent genetic events in hepatocellular carcinoma (HCC). T-box transcription factor 3 (TBX3) is a liver-specific target of the Wnt/β-catenin pathway and thought to be an oncogene mediating activated β-catenin-driven HCC formation.<h4>Methods</h4>We evaluated the expression pattern of TBX3 in human HCC specimens. Tbx3 was conditionally knocked out in murine HCC models by hydrodynamic tail vein injection of Cre together with c-Met and ΔN90-β-catenin (c-Met/β-catenin) in Tbx3<sup>flox/flox</sup> mice. TBX3 was overexpressed in human HCC cell lines to investigate the functions of TBX3 in vitro.<h4>Results</h4>A bimodal expression pattern of TBX3 in human HCC samples was detected: high expression","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-08T01:13:07.428Z","creation":"2022-07-10T09:34:20.069Z"},"accession":"S-EPMC8217095","cross_references":{"pubmed":["33577921"],"doi":["10.1016/j.jhep.2021.01.044"]}}