{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ying KE"],"funding":["NIDDK NIH HHS","National Institutes of Health","US Department of Veterans Affairs","CSRD VA"],"pagination":["80-90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8217262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["171"],"pubmed_abstract":["A major cause of morbidity and mortality in multiple myeloma is kidney injury from overproduction of monoclonal immunoglobulin light chains (FLC). FLC can induce damage through the production of hydrogen peroxide, which activates pro-inflammatory and pro-apoptotic pathways. The present study focused on catalase, a highly conserved antioxidant enzyme that degrades hydrogen peroxide. Initial findings were that FLC increased hydrogen peroxide levels but also decreased catalase levels and activity in proximal tubule epithelium. In order to clarify, we showed that the phosphatidylinositol 3-kinase inhibitor, LY294002, inhibited FLC-induced Akt-mediated deactivation of Forkhead box O class 3a (FoxO3a) and increased catalase activity in proximal tubule cells. Augmented catalase activity decreased"],"journal":["Free radical biology & medicine"],"pubmed_title":["Cellular antioxidant mechanisms control immunoglobulin light chain-mediated proximal tubule injury."],"pmcid":["PMC8217262"],"funding_grant_id":["P30 DK079337","I01 CX001326"],"pubmed_authors":["Ying KE","Sanders PW","Feng W","Ying WZ"],"additional_accession":[]},"is_claimable":false,"name":"Cellular antioxidant mechanisms control immunoglobulin light chain-mediated proximal tubule injury.","description":"A major cause of morbidity and mortality in multiple myeloma is kidney injury from overproduction of monoclonal immunoglobulin light chains (FLC). FLC can induce damage through the production of hydrogen peroxide, which activates pro-inflammatory and pro-apoptotic pathways. The present study focused on catalase, a highly conserved antioxidant enzyme that degrades hydrogen peroxide. Initial findings were that FLC increased hydrogen peroxide levels but also decreased catalase levels and activity in proximal tubule epithelium. In order to clarify, we showed that the phosphatidylinositol 3-kinase inhibitor, LY294002, inhibited FLC-induced Akt-mediated deactivation of Forkhead box O class 3a (FoxO3a) and increased catalase activity in proximal tubule cells. Augmented catalase activity decreased","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-27T00:05:57.061Z","creation":"2025-04-06T17:47:56.498Z"},"accession":"S-EPMC8217262","cross_references":{"pubmed":["33989758"],"doi":["10.1016/j.freeradbiomed.2021.05.011"]}}