biostudies-literatureUnknown4(1)Bonomo P<h4>Purpose</h4>Response assessment to definitive non-surgical treatment for head and neck squamous cell carcinoma (HNSCC) is centered on the role of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET-CT) 12 weeks after treatment. The 5-point Hopkins score is the only qualitative system available for standardized reporting, albeit limited by suboptimal positive predictive value (PPV). The aim of our study was to explore the feasibility and assess the diagnostic accuracy of an experimental 6-point scale ("Cuneo score").<h4>Methods</h4>We performed a retrospective, multicenter study on HNSCC patients who received a curatively-intended, radiation-based treatment. A centralized, independent qualitative evaluation of post-treatment FDG-PET/CT scans wasEuropean journal of hybrid imaging8https://www.ebi.ac.uk/biostudies/studies/S-EPMC8218061biostudies-literatureDoes a 6-point scale approach to post-treatment 18F-FDG PET-CT allow to improve response assessment in head and neck squamous cell carcinoma? A multicenter study.PMC8218061Cauda SBelgioia LAlterio DUrsino SBerretta LCasolo AScalone FRoncali MLivi LBelli GDesideri IVolterrani DVigo FRussi EMorbelli SBergesio FLopci EBianchi ABonomo PCicchetti STravaini LSaieva CBerti VMerlotti APirro VBacigalupo AFranzese CD'Angelo EfalseDoes a 6-point scale approach to post-treatment 18F-FDG PET-CT allow to improve response assessment in head and neck squamous cell carcinoma? A multicenter study.<h4>Purpose</h4>Response assessment to definitive non-surgical treatment for head and neck squamous cell carcinoma (HNSCC) is centered on the role of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET-CT) 12 weeks after treatment. The 5-point Hopkins score is the only qualitative system available for standardized reporting, albeit limited by suboptimal positive predictive value (PPV). The aim of our study was to explore the feasibility and assess the diagnostic accuracy of an experimental 6-point scale ("Cuneo score").<h4>Methods</h4>We performed a retrospective, multicenter study on HNSCC patients who received a curatively-intended, radiation-based treatment. A centralized, independent qualitative evaluation of post-treatment FDG-PET/CT scans was2020-01-01T00:00:00Z2020 May2025-04-22T15:51:40.324Z2022-02-10T17:13:47.21ZS-EPMC82180613419117110.1186/s41824-020-00077-9