{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(6)"],"submitter":["Chen X"],"pubmed_abstract":["Benign prostatic hyperplasia (BPH) is a common disease that occurs mainly in older men. The pathogenesis of BPH is complex and patients face a prolonged treatment course, and novel drugs with better selectivity and lower toxicity are required. Incaspitolide A (compound TMJ-12) is a germacrane-type sesquiterpenoid compound extracted from the plant Carpesium carnuum. Extracts of C. carnuum are known to exert suppressive effects on BPH-1 cells. In the present study, we investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G2/M phase cell cycle arrest and the apoptosis of BPH-1 cells. TMJ-12 was also shown"],"journal":["Bioscience reports"],"pagination":["BSR20210477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8220449"],"repository":["biostudies-literature"],"pubmed_title":["Incaspitolide A extracted from Carpesium cernuum induces apoptosis in vitro via the PI3K/AKT pathway in benign prostatic hyperplasia."],"pmcid":["PMC8220449"],"pubmed_authors":["Yuan D","Rao Q","Jiang K","Li Y","Zhu J","Yan C","Chen X","Zhu G","Feng S","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Incaspitolide A extracted from Carpesium cernuum induces apoptosis in vitro via the PI3K/AKT pathway in benign prostatic hyperplasia.","description":"Benign prostatic hyperplasia (BPH) is a common disease that occurs mainly in older men. The pathogenesis of BPH is complex and patients face a prolonged treatment course, and novel drugs with better selectivity and lower toxicity are required. Incaspitolide A (compound TMJ-12) is a germacrane-type sesquiterpenoid compound extracted from the plant Carpesium carnuum. Extracts of C. carnuum are known to exert suppressive effects on BPH-1 cells. In the present study, we investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G2/M phase cell cycle arrest and the apoptosis of BPH-1 cells. TMJ-12 was also shown","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-09T06:40:59.449Z","creation":"2022-02-10T18:30:38.167Z"},"accession":"S-EPMC8220449","cross_references":{"pubmed":["34100062"],"doi":["10.1042/BSR20210477"]}}