{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sheng X"],"funding":["Science and Technology Commission of Shanghai Municipality","Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University","Shanghai Collaborative Innovation Center for Translational Medicine","Shanghai Natural Science Foundation","National Natural Science Foundation of China","the Shanghai Rising Stars of Medical Talent Youth Development Program for Outstanding Youth Medical Talents","Clinical Research Plan of SHDC","Shanghai Municipal Key Clinical Specialty","the Nurturing Fund of Renji Hospital"],"pagination":["205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8220716"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(1)"],"pubmed_abstract":["<h4>Background</h4>Triple negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and lack of effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis and identified CARMN as a downregulated lncRNA which is lowest expressed in TNBC. We aimed to identify the potential role and molecular mechanisms of CARMN in TNBC.<h4>Methods</h4>Predictive value of CARMN was explored in breast cancer cohorts. TNBC cell lines with CARMN overexpression or CARMN silence and were used for in vitro and in vivo experiments. RNA-seq of CARMN overexpressed cells was performed for exploring downstream of CARMN.<h4>Results</h4>CARMN is downregulated at different phase of malignant transformation of breast tissue. CARMN can predict both bett"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["LncRNA CARMN overexpression promotes prognosis and chemosensitivity of triple negative breast cancer via acting as miR143-3p host gene and inhibiting DNA replication."],"pmcid":["PMC8220716"],"funding_grant_id":["ZH2018QNA42","PYMDT-002","2018-16","82002777","YG2019QNA26","19ZR1431100","TM201908","SHDC2020CR3003A","20DZ2201600"],"pubmed_authors":["Sheng X","Zhou L","Yin W","Lu J","Xu S","Du Y","Lin Y","Sha R","Peng J","Yang F","Wu Y","Dai H"],"additional_accession":[]},"is_claimable":false,"name":"LncRNA CARMN overexpression promotes prognosis and chemosensitivity of triple negative breast cancer via acting as miR143-3p host gene and inhibiting DNA replication.","description":"<h4>Background</h4>Triple negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and lack of effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis and identified CARMN as a downregulated lncRNA which is lowest expressed in TNBC. We aimed to identify the potential role and molecular mechanisms of CARMN in TNBC.<h4>Methods</h4>Predictive value of CARMN was explored in breast cancer cohorts. TNBC cell lines with CARMN overexpression or CARMN silence and were used for in vitro and in vivo experiments. RNA-seq of CARMN overexpressed cells was performed for exploring downstream of CARMN.<h4>Results</h4>CARMN is downregulated at different phase of malignant transformation of breast tissue. CARMN can predict both bett","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-09T09:03:48.647Z","creation":"2022-02-10T16:44:38.717Z"},"accession":"S-EPMC8220716","cross_references":{"pubmed":["34162418"],"doi":["10.1186/s13046-021-02015-4"]}}