biostudies-literatureBurton-Pimentel KJJoint Programming Initiative A healthy diet for a healthy lifeNational Children&apos;s Research Centree2000647https://www.ebi.ac.uk/biostudies/studies/S-EPMC8221028biostudies-literatureUnknown65(4)<h4>Scope</h4>Combining different "omics" data types in a single, integrated analysis may better characterize the effects of diet on human health.<h4>Methods and results</h4>The performance of two data integration tools, similarity network fusion tool (SNFtool) and Data Integration Analysis for Biomarker discovery using Latent variable approaches for "Omics" (DIABLO; MixOmics), in discriminating responses to diet and metabolic phenotypes is investigated by combining transcriptomics and metabolomics datasets from three human intervention studies: a postprandial crossover study testing dairy foods (n = 7; study 1), a postprandial challenge study comparing obese and non-obese subjects (n = 13; study 2); and an 8-week parallel intervention study that assessed three diets with variable lipid coMolecular nutrition & food researchDiscriminating Dietary Responses by Combining Transcriptomics and Metabolomics Data in Nutrition Intervention Studies.PMC822102814/JP‐HDHL/B3076B/11/1Afman LAHughes MPimentel GIbberson MVergeres GMichielsen CCVionnet NRoche HMBurton-Pimentel KJFatima ABrennan LfalseDiscriminating Dietary Responses by Combining Transcriptomics and Metabolomics Data in Nutrition Intervention Studies.<h4>Scope</h4>Combining different "omics" data types in a single, integrated analysis may better characterize the effects of diet on human health.<h4>Methods and results</h4>The performance of two data integration tools, similarity network fusion tool (SNFtool) and Data Integration Analysis for Biomarker discovery using Latent variable approaches for "Omics" (DIABLO; MixOmics), in discriminating responses to diet and metabolic phenotypes is investigated by combining transcriptomics and metabolomics datasets from three human intervention studies: a postprandial crossover study testing dairy foods (n = 7; study 1), a postprandial challenge study comparing obese and non-obese subjects (n = 13; study 2); and an 8-week parallel intervention study that assessed three diets with variable lipid co2021-01-01T00:00:00Z2021 Feb2026-05-08T17:47:41.758Z2022-02-10T17:15:37.974ZS-EPMC82210283332564110.1002/mnfr.202000647