{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alfi O"],"funding":["Samueli Institute (Samueli Institute for Information Biology)","Rothschild Foundation Hanadiv Europe (Rothschild Foundation (Europe))","Rothschild Foundation Hanadiv Europe (Rothschild Foundation","Samueli Institute","Israel Science Foundation","Israel Science Foundation (ISF)","Israeli Ministry of Science &amp; Technology","7th Framework Program ERA-NET","Israeli Science Ministry"],"pagination":["e0013021"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8223920"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(14)"],"pubmed_abstract":["The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the imbalanced innate immune response of end-stage coronavirus disease 2019 (COVID-19) has been extensively studied, the earliest stages of SARS-CoV-2 infection at the mucosal entry site have remained unexplored. Here, we employed SARS-CoV-2 and influenza virus infection in native multi-cell-type human nasal turbinate and lung tissues <i>ex vivo</i>, coupled with genome-wide transcriptional analysis, to investigate viral susceptibility and early patterns of local mucosal innate immune response in the authentic milieu of the human respiratory tract. SARS-CoV-2 productively infected the nasal turbinate tissues, predominantly targeting resp"],"journal":["Journal of virology"],"pubmed_title":["Human Nasal and Lung Tissues Infected <i>Ex Vivo</i> with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract."],"pmcid":["PMC8223920"],"funding_grant_id":["530/18","3-16964"],"pubmed_authors":["Izhar U","Jonas W","Madgar O","Elgavish S","Ives J","Oberbaum M","Nevo Y","Walter J","Pikarsky E","Yakirevitch A","Wald O","Bronstein M","Alfi O","Zakay-Rones Z","Wolf DG","Dagan E","Feinmesser G","Panet A","Vorontsov O","Wandel O","Oiknine-Djian E"],"additional_accession":[]},"is_claimable":false,"name":"Human Nasal and Lung Tissues Infected <i>Ex Vivo</i> with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract.","description":"The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the imbalanced innate immune response of end-stage coronavirus disease 2019 (COVID-19) has been extensively studied, the earliest stages of SARS-CoV-2 infection at the mucosal entry site have remained unexplored. Here, we employed SARS-CoV-2 and influenza virus infection in native multi-cell-type human nasal turbinate and lung tissues <i>ex vivo</i>, coupled with genome-wide transcriptional analysis, to investigate viral susceptibility and early patterns of local mucosal innate immune response in the authentic milieu of the human respiratory tract. SARS-CoV-2 productively infected the nasal turbinate tissues, predominantly targeting resp","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-04T11:12:42.696Z","creation":"2022-02-11T14:29:06.534Z"},"accession":"S-EPMC8223920","cross_references":{"pubmed":["33893170"],"doi":["10.1128/jvi.00130-21","10.1128/JVI.00130-21"]}}