biostudies-literatureYi YNIDDK NIH HHS735-740https://www.ebi.ac.uk/biostudies/studies/S-EPMC8225549biostudies-literatureUnknown28(7)<h4>Objective</h4>Women with type 1 diabetes (T1D) are thought to experience menopause earlier than women without diabetes, although not all studies agree. We assessed metabolic predictors of the age at which natural menopause occurs among women with T1D participating in the Epidemiology of Diabetes Complications study.<h4>Methods</h4>Women with childhood-onset (<17 y) of T1D who underwent natural menopause without use of hormone therapy during their menopausal transition were included in the analysis (n = 105; mean baseline age, 29.5 and diabetes duration, 20.2 y). Self-reported reproductive history and the Women's Ischemia Syndrome Evaluation hormonal algorithms were used to determine menopause status. Linear regression was used to ascertain whether time-weighted metabolic factors (eg, BMenopause (New York, N.Y.)Predictors of the age at which natural menopause occurs in women with type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications (EDC) study.PMC8225549R37 DK034818R01 DK034818Orchard TJYi YRubinstein DCostacou TMiller RGEl Khoudary SRBuchanich JMfalsePredictors of the age at which natural menopause occurs in women with type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications (EDC) study.<h4>Objective</h4>Women with type 1 diabetes (T1D) are thought to experience menopause earlier than women without diabetes, although not all studies agree. We assessed metabolic predictors of the age at which natural menopause occurs among women with T1D participating in the Epidemiology of Diabetes Complications study.<h4>Methods</h4>Women with childhood-onset (<17 y) of T1D who underwent natural menopause without use of hormone therapy during their menopausal transition were included in the analysis (n = 105; mean baseline age, 29.5 and diabetes duration, 20.2 y). Self-reported reproductive history and the Women's Ischemia Syndrome Evaluation hormonal algorithms were used to determine menopause status. Linear regression was used to ascertain whether time-weighted metabolic factors (eg, B2021-01-01T00:00:00Z2021 Apr2025-04-05T10:03:52.245Z2025-04-05T10:03:52.245ZS-EPMC82255493382803510.1097/GME.000000000000177210.1097/gme.0000000000001772