biostudies-literature00390Unknown19(1)Xue T<h4>Background</h4>This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients.<h4>Methods</h4>Tissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan-Meier method was used for survival analysis. Cox proportional hazards analysis was used for univariate analysis and multivariate analysis of clinically relevant confounders.<h4>Results</h4>The samples were divided into low-level (n = 105) and high-level infiltration groups (n = 104) by the median number of CD163+ TAMs detected. The overall survival (OS) and disease-free survival (DFS) of CRC patients in the low-level CD163+ TAM infiltration group were longer than those in the high-level CD163+ TAM infiltration group (P < 0.001). Infiltration of CD163+ TAMs in CRC tissues was a negative prognostic factor for CRC patients. Risks of death and disease recurrence for CRC patients in the low-level CD163+ TAM infiltration group were lower than those in the high-level CD163+ TAM infiltration group (HR_OS = 0.183, 95% CI 0.052-0.647, P = 0.008; HR_DFS = 0.191, 95% CI 0.078-0.470, P = 0.000).<h4>Conclusions</h4>The infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients. High-level infiltration of CD163+ TAMs is associated with shorter OS and DFS.World journal of surgical oncology186https://www.ebi.ac.uk/biostudies/studies/S-EPMC8229299biostudies-literaturePrognostic significance of CD163+ tumor-associated macrophages in colorectal cancer.PMC8229299Xue TYan KChen ZCai YChen XWu WSun J39falsePrognostic significance of CD163+ tumor-associated macrophages in colorectal cancer.<h4>Background</h4>This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients.<h4>Methods</h4>Tissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan-Meier method was used for survival analysis. Cox proportional hazards analysis was used for univariate analysis and multivariate analysis of clinically relevant confounders.<h4>Results</h4>The samples were divided into low-level (n = 105) and high-level infiltration groups (n = 104) by the median number of CD163+ TAMs detected. The overall survival (OS) and disease-free survival (DFS) of CRC patients in the low-level CD163+ TAM infiltration group were longer than those in the high-level CD163+ TAM infiltration group (P < 0.001). Infiltration of CD163+ TAMs in CRC tissues was a negative prognostic factor for CRC patients. Risks of death and disease recurrence for CRC patients in the low-level CD163+ TAM infiltration group were lower than those in the high-level CD163+ TAM infiltration group (HR_OS = 0.183, 95% CI 0.052-0.647, P = 0.008; HR_DFS = 0.191, 95% CI 0.078-0.470, P = 0.000).<h4>Conclusions</h4>The infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients. High-level infiltration of CD163+ TAMs is associated with shorter OS and DFS.2021-01-01T00:00:00Z2021 Jun2024-12-03T22:41:40.43Z2022-02-10T17:17:35.8ZS-EPMC82292993416756110.1186/s12957-021-02299-y