biostudies-literaturePaploski IADNIFA-NSF-NIH-BBSRC Ecology and Evolution of Infectious DiseaseBiotechnology and Biological Sciences Research CouncilUSDA National Institute of Food and Agriculture608https://www.ebi.ac.uk/biostudies/studies/S-EPMC8229766biostudies-literatureUnknown9(6)The genetic diversity and frequent emergence of novel genetic variants of porcine reproductive and respiratory syndrome virus type-2 (PRRSV) hinders control efforts, yet drivers of macro-evolutionary patterns of PRRSV remain poorly documented. Utilizing a comprehensive database of >20,000 <i>orf5</i> sequences, our objective was to classify variants according to the phylogenetic structure of PRRSV co-circulating in the U.S., quantify evolutionary dynamics of sub-lineage emergence, and describe potential antigenic differences among sub-lineages. We subdivided the most prevalent lineage (Lineage 1, accounting for approximately 60% of available sequences) into eight sub-lineages. Bayesian coalescent SkyGrid models were used to estimate each sub-lineage's effective population size over time. WVaccinesPhylogenetic Structure and Sequential Dominance of Sub-Lineages of PRRSV Type-2 Lineage 1 in the United States.PMC82297662019-67015-29918BBS/E/D/10002070BB/T004401/1Kao RRLycett SPaploski IADMakau DNCorzo CAPamornchainavakul NSchroeder DCVanderWaal KRovira ADoeschl-Wilson ACheeran MCfalsePhylogenetic Structure and Sequential Dominance of Sub-Lineages of PRRSV Type-2 Lineage 1 in the United States.The genetic diversity and frequent emergence of novel genetic variants of porcine reproductive and respiratory syndrome virus type-2 (PRRSV) hinders control efforts, yet drivers of macro-evolutionary patterns of PRRSV remain poorly documented. Utilizing a comprehensive database of >20,000 <i>orf5</i> sequences, our objective was to classify variants according to the phylogenetic structure of PRRSV co-circulating in the U.S., quantify evolutionary dynamics of sub-lineage emergence, and describe potential antigenic differences among sub-lineages. We subdivided the most prevalent lineage (Lineage 1, accounting for approximately 60% of available sequences) into eight sub-lineages. Bayesian coalescent SkyGrid models were used to estimate each sub-lineage's effective population size over time. W2021-01-01T00:00:00Z2021 Jun2026-07-09T11:36:18.685Z2022-02-10T19:49:07.395ZS-EPMC82297663419890410.3390/vaccines9060608