{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Orhan E"],"funding":["SIRIC Montpellier Cancer"],"pagination":["2930"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8230762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["The RAD51 recombinase is a critical effector of Homologous Recombination (HR), which is an essential DNA repair mechanism for double-strand breaks. The RAD51 protein is recruited onto the DNA break by BRCA2 and forms homopolymeric filaments that invade the homologous chromatid and use it as a template for repair. RAD51 filaments are detectable by immunofluorescence as distinct foci in the cell nucleus, and their presence is a read out of HR proficiency. RAD51 is an essential gene, protecting cells from genetic instability. Its expression is low and tightly regulated in normal cells and, contrastingly, elevated in a large fraction of cancers, where its level of expression and activity have been linked with sensitivity to genotoxic treatment. In particular, BRCA-deficient tumors show reduced"],"journal":["Cancers"],"pubmed_title":["Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?"],"pmcid":["PMC8230762"],"funding_grant_id":["Grant INCa-DGOS-Inserm_12553"],"pubmed_authors":["Theillet C","Sardet C","Velazquez C","Orhan E","Tabet I"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?","description":"The RAD51 recombinase is a critical effector of Homologous Recombination (HR), which is an essential DNA repair mechanism for double-strand breaks. The RAD51 protein is recruited onto the DNA break by BRCA2 and forms homopolymeric filaments that invade the homologous chromatid and use it as a template for repair. RAD51 filaments are detectable by immunofluorescence as distinct foci in the cell nucleus, and their presence is a read out of HR proficiency. RAD51 is an essential gene, protecting cells from genetic instability. Its expression is low and tightly regulated in normal cells and, contrastingly, elevated in a large fraction of cancers, where its level of expression and activity have been linked with sensitivity to genotoxic treatment. In particular, BRCA-deficient tumors show reduced","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-04-08T09:18:08.878Z","creation":"2022-02-10T18:04:36.816Z"},"accession":"S-EPMC8230762","cross_references":{"pubmed":["34208195"],"doi":["10.3390/cancers13122930"]}}